Production of pharmaceutical proteins by transgenic animals

LM Houdebine - Comparative immunology, microbiology and infectious …, 2009 - Elsevier
Proteins started being used as pharmaceuticals in the 1920s with insulin extracted from pig
pancreas. In the early 1980s, human insulin was prepared in recombinant bacteria and it is …

Use of transgenic animals in biotechnology: prospects and problems

OG Maksimenko, AV Deykin… - Acta Naturae …, 2013 - cyberleninka.ru
During the past two decades, there have been numerous attempts at using animals in order
to produce recombinant human proteins and monoclonal antibodies. However, it is only …

Bioengineering of antibody fragments: challenges and opportunities

S Pirkalkhoran, WR Grabowska, HH Kashkoli… - Bioengineering, 2023 - mdpi.com
Antibody fragments are used in the clinic as important therapeutic proteins for treatment of
indications where better tissue penetration and less immunogenic molecules are needed …

Towards automatic Web genre identification: a corpus-based approach in the domain of academia by example of the Academic's Personal Homepage

G Rehm - Proceedings of the 35th Annual Hawaii International …, 2002 - ieeexplore.ieee.org
We argue for a systematic analysis of one particular, well structured domain-academic Web
pages-with regard to a special class of digital genres: Web genres. For this purpose, we …

Preparation of recombinant vaccines

E Soler, LM Houdebine - Biotechnology annual review, 2007 - Elsevier
Vaccination is one of the most efficient ways to eradicate some infectious diseases in
humans and animals. The material traditionally used as vaccines is attenuated or inactivated …

miR-BAG: bagging based identification of microRNA precursors

A Jha, R Chauhan, M Mehra, HR Singh, R Shankar - 2012 - journals.plos.org
Non-coding elements such as miRNAs play key regulatory roles in living systems. These
ultra-short,∼ 21 bp long, RNA molecules are derived from their hairpin precursors and …

Biosafety, risk assessment, and regulation of molecular farming

PAC Hundleby, M Sack… - … , and Emerging Areas, 2018 - Wiley Online Library
The use of genetically modified plants or plant cells to synthesize proteins that are
subsequently processed, regulated, and sold as pharmaceuticals, cosmetics, or industrial …

Использование трансгенных животных в биотехнологии: перспективы и проблемы

ОГ Максименко, АВ Дейкин… - Acta Naturae …, 2013 - cyberleninka.ru
В течение последних 20 лет предпринимались многочисленные попытки
использования животных для производства рекомбинантных белков человека и …

Isolation and functional characterization of buffalo (Bubalus bubalis) β-casein promoter for driving mammary epithelial cell-specific gene expression

N Ganguli, N Ganguli, A Usmani, SS Majumdar - Journal of biotechnology, 2015 - Elsevier
Therapeutic proteins are produced in microbes, mammalian cell lines, and body fluids by
applying recombinant DNA technology. They are required for compensating the deficiency …

Expression of active fluorophore proteins in the milk of transgenic pigs bypassing the secretory pathway

A Mukherjee, W Garrels, TR Talluri, D Tiedemann… - Scientific reports, 2016 - nature.com
We describe the expression of recombinant fluorescent proteins in the milk of two lines of
transgenic pigs generated by Slee** Beauty transposon-mediated genetic engineering …