Biological hypotheses, risk factors, and biomarkers of schizophrenia

Z Fišar - Progress in neuro-psychopharmacology and Biological …, 2023 - Elsevier
Both the discovery of biomarkers of schizophrenia and the verification of biological
hypotheses of schizophrenia are an essential part of the process of understanding the …

Neuroimaging in schizophrenia: A review article

M Dabiri, F Dehghani Firouzabadi, K Yang… - Frontiers in …, 2022 - frontiersin.org
In this review article we have consolidated the imaging literature of patients with
schizophrenia across the full spectrum of modalities in radiology including computed …

Critical Roles of the Cysteine–Glutathione Axis in the Production of γ-Glutamyl Peptides in the Nervous System

J Fujii, T Osaki, Y Soma, Y Matsuda - International journal of molecular …, 2023 - mdpi.com
γ-Glutamyl moiety that is attached to the cysteine (Cys) residue in glutathione (GSH) protects
it from peptidase-mediated degradation. The sulfhydryl group of the Cys residue represents …

[HTML][HTML] Oxidative stress and emergence of psychosis

V Rambaud, A Marzo, B Chaumette - Antioxidants, 2022 - mdpi.com
Treatment and prevention strategies for schizophrenia require knowledge about the
mechanisms involved in the psychotic transition. Increasing evidence suggests a redox …

Schizophrenia synaptic pathology and antipsychotic treatment in the framework of oxidative and mitochondrial dysfunction: translational highlights for the clinics and …

G De Simone, B Mazza, L Vellucci, A Barone… - Antioxidants, 2023 - mdpi.com
Schizophrenia is a worldwide mental illness characterized by alterations at dopaminergic
and glutamatergic synapses resulting in global dysconnectivity within and between brain …

[HTML][HTML] Decreased activity of erythrocyte catalase and glutathione peroxidase in patients with schizophrenia

VV Djordjević, J Kostić, Ž Krivokapić, D Krtinić… - Medicina, 2022 - mdpi.com
Background and Objectives: Catalase and glutathione peroxidase (GPx) are important
antioxidant enzymes that break down hydrogen peroxide (H2O2) in order to control its …

Progress and pitfalls in develo** agents to treat neurocognitive deficits associated with schizophrenia

T Veselinović, I Neuner - CNS drugs, 2022 - Springer
Cognitive impairments associated with schizophrenia (CIAS) represent a central element of
the symptomatology of this severe mental disorder. CIAS substantially determine the …

Comparative analysis of the pre-and post-medication effects of antipsychotic agents on the blood-based oxidative stress biomarkers in patients with schizophrenia: a …

M Yang, C Wang, G Zhao, D Kong, L Liu… - Current …, 2023 - benthamdirect.com
Objective: Studies have shown that oxidative stress (OS) is related to the pathophysiology of
schizophrenia (SCZ), but whether antipsychotics can induce OS has not been investigated …

Schizophrenia increases variability of the central antioxidant system: a meta-analysis of variance from MRS studies of glutathione

L Palaniyappan, P Sabesan, X Li, Q Luo - Frontiers in psychiatry, 2021 - frontiersin.org
Patients with schizophrenia diverge in their clinical trajectories. Such diverge outcomes may
result from the resilience provided by antioxidant response system centered on glutathione …

Alterations in TRN-anterodorsal thalamocortical circuits affect sleep architecture and homeostatic processes in oxidative stress vulnerable Gclm−/− mice

C Czekus, P Steullet, A Orero López, I Bozic… - Molecular …, 2022 - nature.com
Schizophrenia is associated with alterations of sensory integration, cognitive processing and
both sleep architecture and sleep oscillations in mouse models and human subjects …