Glucocorticoid action on target tissues is determined by the density of “nuclear” receptors
and intracellular metabolism by the two isozymes of 11β-hydroxysteroid dehydrogenase …

Significance: Severe life stress (SLS), as opposed to trivial everyday stress, is defined as a
serious psychosocial event with the potential of causing an impacting psychological …

Objective To study the relationship between self-reported exposure to childhood
maltreatment (CM) and cerebral gray matter (GM) morphology in adolescents without …

Glucocorticoids have profound effects on brain development and adult CNS function. Excess
or insufficient glucocorticoids cause myriad abnormalities from development to ageing. The …

Irritable bowel syndrome is a functional gastrointestinal disorder, with stress playing a major
role in onset and exacerbation of symptoms such as abdominal pain and altered bowel …

Fetal glucocorticoid exposure is a key mechanism proposed to underlie prenatal
'programming'of adult affective behaviours such as depression and anxiety. Indeed, the …

Many children suffer from neurodevelopmental aberrations that have long-term effects. To
understand the consequences of pathological processes during particular periods in …

Early-life stress (ELS) is associated with later onset of depression. Early cannabis use may
be a risk factor that interacts with environmental factors to increase the risk of …

Emerging evidence points to the role of the endocannabinoid system in long-term stress-
induced neural remodeling with studies on stress-induced endocannabinoid dysregulation …

A growing body of findings underlines the critical role of the early environment in normal
growth and development. Human studies suggest that severe stress during childhood …