Since their inaugural discovery in the early 1960s, matrix metalloproteinases (MMPs) have
been shown to mediate multiple physiological and pathological processes. In addition to …

Diabetic cardiomyopathy (DCM), characterized by mitochondrial dysfunction and impaired
energetics as contributing factors, significantly contributes to high mortality in patients with …

Caveolae are omega-shaped membrane invaginations present in essentially all cell types of
the cardiovascular system, including endothelial cells, smooth muscle cells, macrophages …

It has been proposed that membrane microdomains, caveolae, in vascular cells are critical
for signal transduction and downstream functions induced by angiotensin II (AngII). We have …

The cardiac response to myocardial injury includes fibrotic and hypertrophic processes and
a key mediator in this response is transforming growth factor-β1 (TGF-β1). Caveolin-1 …

Abstract Purpose Matrix metalloproteinases (MMPs) are identified as modulators of the
extracellular matrix in heart failure progression. However, evidence for intracellular effects of …

Caveolae and associated cavin and caveolins may govern myocardial function, together
with responses to mechanical and ischaemic stresses. Abnormalities in these proteins are …

BACKGROUND: Caveolar raft domains, also termed caveolae, are flask shaped
invaginations that require the expression of the structural protein caveolin-1 (cav-1). Matrix …

Binding of ouabain to cardiac Na+/K+-ATPase initiates cell signaling and causes contractility
in cardiomyocytes. It is widely accepted that caveolins, structural proteins of caveolae, have …

Stem cell differentiation into a variety of lineages is known to involve signaling from the
extracellular niche, including from the physical properties of that environment. What …