Structures of 70 unique G protein-coupled receptors (GPCRs) have been determined, with
over 370 structures in total bound to different ligands and the receptors in various …

G protein-coupled receptors (GPCRs) are the largest single family of cell surface receptors
encoded by the human genome and they play pivotal roles in co-ordinating cellular systems …

Our sense of smell enables us to navigate a vast space of chemically diverse odour
molecules. This task is accomplished by the combinatorial activation of approximately 400 …

Class A G-protein-coupled receptors (GPCRs) influence virtually every aspect of human
physiology. Understanding receptor activation mechanism is critical for discovering novel …

Advances in electron cryo-microscopy (cryo-EM) now permit the structure determination of G
protein-coupled receptors (GPCRs) coupled to heterotrimeric G proteins by single-particle …

Conformational dynamics are essential for proteins to function. We adapted time-resolved
serial crystallography developed at x-ray lasers to visualize protein motions using …

G protein-coupled receptors (GPCRs) activate four families of heterotrimeric G proteins, and
individual receptors must select a subset of G proteins to produce appropriate cellular …

The CC chemokine receptor 7 (CCR7) balances immunity and tolerance by homeostatic
trafficking of immune cells. In cancer, CCR7-mediated trafficking leads to lymph node …

G protein-coupled receptors (GPCRs) regulate many cellular and physiological processes,
responding to a diverse range of extracellular stimuli including hormones, neurotransmitters …

G-protein-coupled receptors (GPCRs) transduce physiological and sensory stimuli into
appropriate cellular responses and mediate the actions of one-third of drugs. GPCR …