Obesity leads to chronic, systemic inflammation and can lead to insulin resistance (IR), β-cell
dysfunction, and ultimately type 2 diabetes (T2D). This chronic inflammatory state …

The health benefits of exercise are well-recognized and are observed across multiple organ
systems. These beneficial effects enhance overall resilience, healthspan and longevity. The …

Physical activity decreases the risk of a network of diseases, and exercise may be
prescribed as medicine for lifestyle-related disorders such as type 2 diabetes, dementia …

Obesity is one of the major health burdens of the 21st century as it contributes to the growing
prevalence of its related comorbidities, including insulin resistance and type 2 diabetes …

Accumulating evidence indicates that obesity is closely associated with an increased risk of
metabolic diseases such as insulin resistance, type 2 diabetes, dyslipidemia and …

Decades of research in skeletal muscle physiology have provided multiscale insights into
the structural and functional complexity of this important anatomical tissue, designed to …

During the past decade, skeletal muscle has been identified as a secretory organ.
Accordingly, we have suggested that cytokines and other peptides that are produced …

Extensive research has shown that interleukin 6 (IL-6) is a multifunctional molecule that is
both proinflammatory and anti-inflammatory, depending on the context. Here, we combine …

Neurological and mental illnesses account for a considerable proportion of the global
burden of disease. Exercise has many beneficial effects on brain health, contributing to …

In the last several decades, the number of people dying from cancer-related deaths has not
reduced significantly despite phenomenal advances in the technologies related to diagnosis …