Macrophages are important immune cells in innate immunity, and have remarkable
heterogeneity and polarization. Under pathological conditions, in addition to the resident …

The liver communicates with the intestine via the portal vein, biliary system, and mediators in
the circulation. Microbes in the intestine maintain liver homeostasis but can also serve as a …

Background/aims Whereas nonalcoholic fatty liver disease (NAFLD) is a multisystem
disease, the association between metabolic dysfunction-associated fatty liver disease …

Background Hepatobiliary disease currently serves as an urgent health issue in public due
to health-modulating factors such as extension of life expectancy, increasingly sedentary …

Background Alcohol related liver disease (ARLD) is one of the major chronic liver diseases
worldwide. This review aimed to describe the global prevalence, incidence, and outcomes of …

Fatty liver disease associated with metabolic dysfunction is of increasing concern in
mainland China, the world's most populous country. The incidence of fatty liver disease is …

Background & Aims Antiviral therapy improves the clinical outcomes of patients with chronic
hepatitis B (CHB), including those with cirrhosis. In the present study, we validated the …

Liver fibrosis (LF) is a pathological repair reaction caused by a chronic liver injury that affects
the health of millions of people worldwide, progressing to life-threatening cirrhosis and liver …

During liver fibrogenesis, liver sinusoidal capillarization and extracellular matrix (ECM)
deposition construct dual pathological barriers to drug delivery. Upon capillarization, the …

Abstract Background Coronavirus disease 2019 (COVID-19) is an infectious disease
characterized by cough, fever, and fatigue and 20% of cases will develop into severe …