Voltage map** in subcellular nanodomains using electro-diffusion modeling

F Paquin-Lefebvre, D Holcman - The Journal of Chemical Physics, 2024 - pubs.aip.org
Voltage distribution in sub-cellular micro-domains such as neuronal synapses, small
protrusions, or dendritic spines regulates the opening and closing of ionic channels, energy …

[BOOK][B] Asymptotics of Elliptic and Parabolic PDEs

D Holcman, Z Schuss - 2018 - Springer
This book is a summary of modern asymptotic methods for the construction of solutions to
boundary value problems for partial differential equations (PDEs) arising from modern …

Synaptic cleft geometry modulates NMDAR opening probability by tuning neurotransmitter residence time

MH Mesa, K McCabe, P Rangamani - Biophysical Journal, 2025 - cell.com
Synaptic morphology plays a critical role in modulating the dynamics of neurotransmitter
diffusion and receptor activation in interneuron communication. Central physical aspects of …

Voltage laws in nanodomains revealed by asymptotics and simulations of electro-diffusion equations

F Paquin-Lefebvre, AB Moreno, D Holcman - arxiv preprint arxiv …, 2024 - arxiv.org
Characterizing the local voltage distribution within nanophysiological domains, driven by
ionic currents through membrane channels, is crucial for studying cellular activity in modern …

Steady-state voltage distribution in three-dimensional cusp-shaped funnels modeled by PNP

J Cartailler, D Holcman - Journal of mathematical biology, 2019 - Springer
We study here the bulk electro-diffusion properties of micro-and nanodomains containing a
cusp-shaped structure in three-dimensions when the cation concentration dominates over …

Modeling the voltage distribution in a non-locally but globally electroneutral confined electrolyte medium: applications for nanophysiology

A Tricot, IM Sokolov, D Holcman - Journal of Mathematical Biology, 2021 - Springer
The distribution of voltage in sub-micron cellular domains remains poorly understood. In
neurons, the voltage results from the difference in ionic concentrations which are …

Modeling ionic flow between small targets: insights from diffusion and electro-diffusion theory

F Paquin-Lefebvre, D Holcman - Target Search Problems, 2024 - Springer
The flow of ions through permeable channels causes voltage drop in physiological
nanodomains such as synapses, dendrites and dendritic spines and other protrusions. How …

Reply to 'Only negligible deviations from electroneutrality are expected in dendritic spines'

D Holcman, R Yuste - Nature Reviews Neuroscience, 2020 - nature.com
Redefining capacitance In idealized electrolytes as described by Barbour, with equal ionic
concentrations and equal mobility, charges in excess accumulate close to the membrane …

Systems Isomorphisms in Stochastic Dynamic Systems

R Venkatachalapathy - 2020 - search.proquest.com
The identification of isomorphisms between disparate systems is an important focus of
systems science. Such isomorphisms have not only conceptual and pedagogical value to …

Universal Biological Motions for Educational Robot Theatre and Games

R Venkatachalapathy, M Zwick, A Slowik… - … on Information and …, 2021 - ieeexplore.ieee.org
Paper presents a concept that is new to robotics education and social robotics. It is based on
theatrical games, in which students create “biological”,“characteristic” and natural motions …