How glutamate is managed by the blood–brain barrier
RA Hawkins, JR Viña - Biology, 2016 - mdpi.com
A facilitative transport system exists on the blood–brain barrier (BBB) that has been tacitly
assumed to be a path for glutamate entry to the brain. However, glutamate is a non-essential …
assumed to be a path for glutamate entry to the brain. However, glutamate is a non-essential …
Modifying chromatin by histone tail clip**
Post-translational modifications (PTMs) of histone proteins play a crucial role in the
regulation of chromatin structure and functions. Studies in the last few decades have …
regulation of chromatin structure and functions. Studies in the last few decades have …
Extra-nuclear histones: origin, significance and perspectives
Histones are classically known to organize the eukaryotic DNA into chromatin. They are one
of the key players in regulating transcriptionally permissive and non-permissive states of the …
of the key players in regulating transcriptionally permissive and non-permissive states of the …
Evolutionary Changes in Primate Glutamate Dehydrogenases 1 and 2 Influence the Protein Regulation by Ligands, Targeting and Posttranslational Modifications
YA Aleshina, VA Aleshin - International Journal of Molecular Sciences, 2024 - mdpi.com
There are two paralogs of glutamate dehydrogenase (GDH) in humans encoded by the
GLUD1 and GLUD2 genes as a result of a recent retroposition during the evolution of …
GLUD1 and GLUD2 genes as a result of a recent retroposition during the evolution of …
Multiple forms of glutamate dehydrogenase in animals: structural determinants and physiological implications
Glutamate dehydrogenase (GDH) of animal cells is usually considered to be a mitochondrial
enzyme. However, this enzyme has recently been reported to be also present in nucleus …
enzyme. However, this enzyme has recently been reported to be also present in nucleus …
Chromatin is a dynamic DNA scaffold structure that responds to a variety of external and
internal stimuli to regulate the fundamental biological processes. Majority of the cases …
internal stimuli to regulate the fundamental biological processes. Majority of the cases …
Запазване Позоваване С позовавания в 56 Y Xue, AA Vashisht, Y Tan, T Su, JA Wohlschlegel - PLoS One, 2014 - journals.plos.org
Cathepsin L, a lysosomal protein in mouse embryonic stem cells has been shown to clip the
histone H3 N-terminus, an activity associated with gene activity during mouse cell …
histone H3 N-terminus, an activity associated with gene activity during mouse cell …
Evolution of GLUD2 Glutamate Dehydrogenase Allows Expression in Human Cortical Neurons
Human hGDH2 arose via duplication in the apes and driven by positive selection acquired
enhanced catalytic ability under conditions inhibitory to its precursor hGDH1 (common to all …
enhanced catalytic ability under conditions inhibitory to its precursor hGDH1 (common to all …