AKT/PKB signaling: navigating the network
The Ser and Thr kinase AKT, also known as protein kinase B (PKB), was discovered 25
years ago and has been the focus of tens of thousands of studies in diverse fields of biology …
years ago and has been the focus of tens of thousands of studies in diverse fields of biology …
The PI3K/AKT pathway and renal cell carcinoma
The phosphatidylinositol 3 kinase (PI3K)/AKT pathway is genetically targeted in more
pathway components and in more tumor types than any other growth factor signaling …
pathway components and in more tumor types than any other growth factor signaling …
Proteomic and phosphoproteomic landscapes of acute myeloid leukemia
We have developed a deep-scale proteome and phosphoproteome database from 44
representative acute myeloid leukemia (AML) patients from the LAML TCGA dataset and 6 …
representative acute myeloid leukemia (AML) patients from the LAML TCGA dataset and 6 …
Akt kinase activation mechanisms revealed using protein semisynthesis
Akt is a critical protein kinase that drives cancer proliferation, modulates metabolism, and is
activated by C-terminal phosphorylation. The current structural model for Akt activation by C …
activated by C-terminal phosphorylation. The current structural model for Akt activation by C …
New insights into protein kinase B/Akt signaling: role of localized Akt activation and compartment-specific target proteins for the cellular radiation response
Genetic alterations driving aberrant activation of the survival kinase Protein Kinase B (Akt)
are observed with high frequency during malignant transformation and cancer progression …
are observed with high frequency during malignant transformation and cancer progression …
Akt isoforms: a family affair in breast cancer
A Basu, CB Lambring - Cancers, 2021 - mdpi.com
Simple Summary Breast cancer is the second leading cause of cancer-related death in
women in the United States. The Akt signaling pathway is deregulated in approximately 70 …
women in the United States. The Akt signaling pathway is deregulated in approximately 70 …
Identification of XAF1 as an endogenous AKT inhibitor
M Chen, K Wang, Y Han, S Yan, H Yuan, Q Liu, L Li… - Cell Reports, 2023 - cell.com
AKT kinase is a key regulator in cell metabolism and survival, and its activation is strictly
modulated. Herein, we identify XAF1 (XIAP-associated factor) as a direct interacting protein …
modulated. Herein, we identify XAF1 (XIAP-associated factor) as a direct interacting protein …
Proteomic signature of host response to SARS-CoV-2 infection in the nasopharynx
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection, has become a global health pandemic. COVID-19 …
coronavirus 2 (SARS-CoV-2) infection, has become a global health pandemic. COVID-19 …
Dynamic remodelling of the human host cell proteome and phosphoproteome upon enterovirus infection
The group of enteroviruses contains many important pathogens for humans, including
poliovirus, coxsackievirus, rhinovirus, as well as newly emerging global health threats such …
poliovirus, coxsackievirus, rhinovirus, as well as newly emerging global health threats such …
Insulin induction instigates cell proliferation and metastasis in human colorectal cancer cells
The progression of colorectal cancer has been reported to have a positive correlation with
the combination of hyperglycemia and hyperinsulinemia in diabetic patients, leading to a …
the combination of hyperglycemia and hyperinsulinemia in diabetic patients, leading to a …