The Ser and Thr kinase AKT, also known as protein kinase B (PKB), was discovered 25
years ago and has been the focus of tens of thousands of studies in diverse fields of biology …

The phosphatidylinositol 3 kinase (PI3K)/AKT pathway is genetically targeted in more
pathway components and in more tumor types than any other growth factor signaling …

We have developed a deep-scale proteome and phosphoproteome database from 44
representative acute myeloid leukemia (AML) patients from the LAML TCGA dataset and 6 …

Akt is a critical protein kinase that drives cancer proliferation, modulates metabolism, and is
activated by C-terminal phosphorylation. The current structural model for Akt activation by C …

Genetic alterations driving aberrant activation of the survival kinase Protein Kinase B (Akt)
are observed with high frequency during malignant transformation and cancer progression …

Simple Summary Breast cancer is the second leading cause of cancer-related death in
women in the United States. The Akt signaling pathway is deregulated in approximately 70 …

The progression of colorectal cancer has been reported to have a positive correlation with
the combination of hyperglycemia and hyperinsulinemia in diabetic patients, leading to a …

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection, has become a global health pandemic. COVID-19 …

Background Aberrant AKT activation is prevalent across human cancer lineages, providing
an important therapeutic target. AKT comprises three isoforms that mediate critical non …

The group of enteroviruses contains many important pathogens for humans, including
poliovirus, coxsackievirus, rhinovirus, as well as newly emerging global health threats such …