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Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities
The Wnt/β-catenin pathway comprises a family of proteins that play critical roles in
embryonic development and adult tissue homeostasis. The deregulation of Wnt/β-catenin …
embryonic development and adult tissue homeostasis. The deregulation of Wnt/β-catenin …
Wnt/β-catenin signaling pathway in carcinogenesis and cancer therapy
P Song, Z Gao, Y Bao, L Chen, Y Huang, Y Liu… - Journal of Hematology & …, 2024 - Springer
The Wnt/β-catenin signaling pathway plays a crucial role in various physiological processes,
encompassing development, tissue homeostasis, and cell proliferation. Under normal …
encompassing development, tissue homeostasis, and cell proliferation. Under normal …
Targeting the Wnt/β-catenin signaling pathway in cancer
Y Zhang, X Wang - Journal of hematology & oncology, 2020 - Springer
The aberrant Wnt/β-catenin signaling pathway facilitates cancer stem cell renewal, cell
proliferation and differentiation, thus exerting crucial roles in tumorigenesis and therapy …
proliferation and differentiation, thus exerting crucial roles in tumorigenesis and therapy …
Wnt signaling in breast cancer: biological mechanisms, challenges and opportunities
X Xu, M Zhang, F Xu, S Jiang - Molecular cancer, 2020 - Springer
Wnt signaling is a highly conserved signaling pathway that plays a critical role in controlling
embryonic and organ development, as well as cancer progression. Genome-wide …
embryonic and organ development, as well as cancer progression. Genome-wide …
Targeting the Wnt/beta-catenin pathway in cancer: Update on effectors and inhibitors
N Krishnamurthy, R Kurzrock - Cancer treatment reviews, 2018 - Elsevier
The Wnt/beta-catenin pathway is a family of proteins that is implicated in many vital cellular
functions such as stem cell regeneration and organogenesis. Several intra-cellular signal …
functions such as stem cell regeneration and organogenesis. Several intra-cellular signal …
[HTML][HTML] Therapeutic potential of targeting the Wnt/β-catenin signaling pathway in colorectal cancer
X Cheng, X Xu, D Chen, F Zhao, W Wang - Biomedicine & …, 2019 - Elsevier
Aberrant Wnt/β-catenin signaling has often been reported in different cancers, particularly
colorectal cancer (CRC), and this signaling cascade is central to carcinogenesis …
colorectal cancer (CRC), and this signaling cascade is central to carcinogenesis …
[HTML][HTML] Transcriptional regulation of Wnt/β-catenin pathway in colorectal cancer
J Bian, M Dannappel, C Wan, R Firestein - Cells, 2020 - mdpi.com
The Wnt/β-catenin signaling pathway exerts integral roles in embryogenesis and adult
homeostasis. Aberrant activation of the pathway is implicated in growth-associated diseases …
homeostasis. Aberrant activation of the pathway is implicated in growth-associated diseases …
Systematic profiling of conditional pathway activation identifies context-dependent synthetic lethalities
L Chang, NY Jung, A Atari, DJ Rodriguez, D Kesar… - Nature Genetics, 2023 - nature.com
The paradigm of cancer-targeted therapies has focused largely on inhibition of critical
pathways in cancer. Conversely, conditional activation of signaling pathways as a new …
pathways in cancer. Conversely, conditional activation of signaling pathways as a new …
Pharmaceuticals targeting signaling pathways of endometriosis as potential new medical treatment: A review
Endometriosis (EM) is defined as endometrial tissues found outside the uterus. Growth and
development of endometriotic cells in ectopic sites can be promoted via multiple pathways …
development of endometriotic cells in ectopic sites can be promoted via multiple pathways …
[HTML][HTML] WNT signaling in disease
Developmental signaling pathways control a vast array of biological processes during
embryogenesis and in adult life. The WNT pathway was discovered simultaneously in …
embryogenesis and in adult life. The WNT pathway was discovered simultaneously in …