Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities

J Liu, Q **ao, J **ao, C Niu, Y Li, X Zhang… - Signal transduction and …, 2022 - nature.com
The Wnt/β-catenin pathway comprises a family of proteins that play critical roles in
embryonic development and adult tissue homeostasis. The deregulation of Wnt/β-catenin …

Wnt/β-catenin signaling pathway in carcinogenesis and cancer therapy

P Song, Z Gao, Y Bao, L Chen, Y Huang, Y Liu… - Journal of Hematology & …, 2024 - Springer
The Wnt/β-catenin signaling pathway plays a crucial role in various physiological processes,
encompassing development, tissue homeostasis, and cell proliferation. Under normal …

Targeting the Wnt/β-catenin signaling pathway in cancer

Y Zhang, X Wang - Journal of hematology & oncology, 2020 - Springer
The aberrant Wnt/β-catenin signaling pathway facilitates cancer stem cell renewal, cell
proliferation and differentiation, thus exerting crucial roles in tumorigenesis and therapy …

Wnt signaling in breast cancer: biological mechanisms, challenges and opportunities

X Xu, M Zhang, F Xu, S Jiang - Molecular cancer, 2020 - Springer
Wnt signaling is a highly conserved signaling pathway that plays a critical role in controlling
embryonic and organ development, as well as cancer progression. Genome-wide …

Targeting the Wnt/beta-catenin pathway in cancer: Update on effectors and inhibitors

N Krishnamurthy, R Kurzrock - Cancer treatment reviews, 2018 - Elsevier
The Wnt/beta-catenin pathway is a family of proteins that is implicated in many vital cellular
functions such as stem cell regeneration and organogenesis. Several intra-cellular signal …

[HTML][HTML] Therapeutic potential of targeting the Wnt/β-catenin signaling pathway in colorectal cancer

X Cheng, X Xu, D Chen, F Zhao, W Wang - Biomedicine & …, 2019 - Elsevier
Aberrant Wnt/β-catenin signaling has often been reported in different cancers, particularly
colorectal cancer (CRC), and this signaling cascade is central to carcinogenesis …

[HTML][HTML] Transcriptional regulation of Wnt/β-catenin pathway in colorectal cancer

J Bian, M Dannappel, C Wan, R Firestein - Cells, 2020 - mdpi.com
The Wnt/β-catenin signaling pathway exerts integral roles in embryogenesis and adult
homeostasis. Aberrant activation of the pathway is implicated in growth-associated diseases …

Systematic profiling of conditional pathway activation identifies context-dependent synthetic lethalities

L Chang, NY Jung, A Atari, DJ Rodriguez, D Kesar… - Nature Genetics, 2023 - nature.com
The paradigm of cancer-targeted therapies has focused largely on inhibition of critical
pathways in cancer. Conversely, conditional activation of signaling pathways as a new …

Pharmaceuticals targeting signaling pathways of endometriosis as potential new medical treatment: A review

SW Hung, R Zhang, Z Tan, JPW Chung… - Medicinal research …, 2021 - Wiley Online Library
Endometriosis (EM) is defined as endometrial tissues found outside the uterus. Growth and
development of endometriotic cells in ectopic sites can be promoted via multiple pathways …

[HTML][HTML] WNT signaling in disease

LF Ng, P Kaur, N Bunnag, J Suresh, ICH Sung, QH Tan… - Cells, 2019 - mdpi.com
Developmental signaling pathways control a vast array of biological processes during
embryogenesis and in adult life. The WNT pathway was discovered simultaneously in …