The role of ubiquitination in tumorigenesis and targeted drug discovery
Ubiquitination, an important type of protein posttranslational modification (PTM), plays a
crucial role in controlling substrate degradation and subsequently mediates the “quantity” …
crucial role in controlling substrate degradation and subsequently mediates the “quantity” …
Genetics and biology of prostate cancer
Despite the high long-term survival in localized prostate cancer, metastatic prostate cancer
remains largely incurable even after intensive multimodal therapy. The lethality of advanced …
remains largely incurable even after intensive multimodal therapy. The lethality of advanced …
The long tail of oncogenic drivers in prostate cancer
Comprehensive genomic characterization of prostate cancer has identified recurrent
alterations in genes involved in androgen signaling, DNA repair, and PI3K signaling, among …
alterations in genes involved in androgen signaling, DNA repair, and PI3K signaling, among …
Divergent clonal evolution of castration-resistant neuroendocrine prostate cancer
An increasingly recognized resistance mechanism to androgen receptor (AR)-directed
therapy in prostate cancer involves epithelial plasticity, in which tumor cells demonstrate low …
therapy in prostate cancer involves epithelial plasticity, in which tumor cells demonstrate low …
Cancer mutations of the tumor suppressor SPOP disrupt the formation of active, phase-separated compartments
JJ Bouchard, JH Otero, DC Scott, E Szulc, EW Martin… - Molecular cell, 2018 - cell.com
Mutations in the tumor suppressor SPOP (speckle-type POZ protein) cause prostate, breast,
and other solid tumors. SPOP is a substrate adaptor of the cullin3-RING ubiquitin ligase and …
and other solid tumors. SPOP is a substrate adaptor of the cullin3-RING ubiquitin ligase and …
Prostate cancer–associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4
The bromodomain and extraterminal (BET) family of proteins comprises four members—
BRD2, BRD3, BRD4 and the testis-specific isoform BRDT—that largely function as …
BRD2, BRD3, BRD4 and the testis-specific isoform BRDT—that largely function as …
TRIM24 is an oncogenic transcriptional activator in prostate cancer
Androgen receptor (AR) signaling is a key driver of prostate cancer (PC). While androgen-
deprivation therapy is transiently effective in advanced disease, tumors often progress to a …
deprivation therapy is transiently effective in advanced disease, tumors often progress to a …
Higher-order SPOP assembly reveals a basis for cancer mutant dysregulation
The speckle-type POZ protein (SPOP) functions in the Cullin3-RING ubiquitin ligase (CRL3)
as a receptor for the recognition of substrates involved in cell growth, survival, and signaling …
as a receptor for the recognition of substrates involved in cell growth, survival, and signaling …
SPOP mutation drives prostate tumorigenesis in vivo through coordinate regulation of PI3K/mTOR and AR signaling
M Blattner, D Liu, BD Robinson, D Huang, A Poliakov… - Cancer cell, 2017 - cell.com
Recurrent point mutations in SPOP define a distinct molecular subclass of prostate cancer.
Here, we describe a mouse model showing that mutant SPOP drives prostate tumorigenesis …
Here, we describe a mouse model showing that mutant SPOP drives prostate tumorigenesis …
Comprehensive assessment of cancer missense mutation clustering in protein structures
A Kamburov, MS Lawrence, P Polak… - Proceedings of the …, 2015 - National Acad Sciences
Large-scale tumor sequencing projects enabled the identification of many new cancer gene
candidates through computational approaches. Here, we describe a general method to …
candidates through computational approaches. Here, we describe a general method to …