Altered adipose tissue and adipocyte function in the pathogenesis of metabolic syndrome
Over the past decade, great progress has been made in understanding the complexity of
adipose tissue biology and its role in metabolism. This includes new insights into the …
adipose tissue biology and its role in metabolism. This includes new insights into the …
Novel CRISPR–Cas systems: an updated review of the current achievements, applications, and future research perspectives
According to Darwin's theory, endless evolution leads to a revolution. One such example is
the Clustered Regularly Interspaced Palindromic Repeats (CRISPR)–Cas system, an …
the Clustered Regularly Interspaced Palindromic Repeats (CRISPR)–Cas system, an …
Gene editing and CRISPR in the clinic: current and future perspectives
Genome editing technologies, particularly those based on zinc-finger nucleases (ZFNs),
transcription activator-like effector nucleases (TALENs), and CRISPR (clustered regularly …
transcription activator-like effector nucleases (TALENs), and CRISPR (clustered regularly …
Genome editing of the HIV co-receptors CCR5 and CXCR4 by CRISPR-Cas9 protects CD4+ T cells from HIV-1 infection
Z Liu, S Chen, X **, Q Wang, K Yang, C Li, Q **, GA Newby, CR Eide, AN McElroy… - Molecular therapy, 2022 - cell.com
Disruption of CCR5 or CXCR4, the main human immunodeficiency virus type 1 (HIV-1) co-
receptors, has been shown to protect primary human CD4+ T cells from HIV-1 infection …
receptors, has been shown to protect primary human CD4+ T cells from HIV-1 infection …
Designer epigenome modifiers enable robust and sustained gene silencing in clinically relevant human cells
T Mlambo, S Nitsch, M Hildenbeutel… - Nucleic acids …, 2018 - academic.oup.com
Targeted modulation of gene expression represents a valuable approach to understand the
mechanisms governing gene regulation. In a therapeutic context, it can be exploited to …
mechanisms governing gene regulation. In a therapeutic context, it can be exploited to …