The MYC proto-oncogenes encode a family of transcription factors that are among the most
commonly activated oncoproteins in human neoplasias. Indeed, MYC aberrations or …

Cancer cells must rewire cellular metabolism to satisfy the demands of unbridled growth and
proliferation. As such, most human cancers differ from normal counterpart tissues by a …

Map** tumor metabolic remodeling and their spatial crosstalk with surrounding non-tumor
cells can fundamentally improve our understanding of tumor biology, facilitates the …

Many human diseases, including metabolic, immune and central nervous system disorders,
as well as cancer, are the consequence of an alteration in lipid metabolic enzymes and their …

We report an atmospheric pressure (AP) matrix-assisted laser desorption/ionization (MALDI)
mass spectrometry imaging (MSI) setup with a lateral resolution of 1.4 μm, a mass resolution …

Characterization of tumor metabolism with spatial information contributes to our
understanding of complex cancer metabolic reprogramming, facilitating the discovery of …

Lipids, either endogenously synthesized or exogenous, have been linked to human cancer.
Here we found that PML is frequently co-deleted with PTEN in metastatic human prostate …

The Siglecs (sialic acid-binding immunoglobulin-like lectins) are glycoimmune checkpoint
receptors that suppress immune cell activation upon engagement of cognate sialoglycan …

Transcription factors of the MYC family are deregulated in the majority of all human cancers.
Oncogenic levels of MYC reprogram cellular metabolism, a hallmark of cancer development …

The MYC oncogene is frequently mutated and overexpressed in human renal cell carcinoma
(RCC). However, there have been no studies on the causative role of MYC or any other …