The pathogenic bacterium Staphylococcus aureus is the most common pathogen isolated in
skin-and-soft-tissue infections (SSTIs) in the United States. Most S. aureus SSTIs are caused …

As a family of cationic host defense peptides, defensins are mainly synthesized by Paneth
cells, neutrophils, and epithelial cells, contributing to host defense. Their biological functions …

The notion that neutrophils exist as a homogeneous population is being replaced with the
knowledge that neutrophils adopt different functional states. Neutrophils can have a pro …

Skin and soft tissue infections (SSTIs) arises from microbial ingress into the skin. In this
study, poly (2-acrylamido-2-methyl-1-propanesulfonic acid)(polyAMPS), which has been …

The discovery of Mas-related G protein-coupled receptors (Mrgprs) has opened a
compelling chapter in our understanding of immunity and sensory biology. This family of …

Infection of the human gut by Salmonella enterica Typhimurium (STM) results in a localized
inflammatory disease that is not mimicked in murine infections. To determine mechanisms …

Human enteric α-defensin 5 (HD5) is an immune system peptide that acts as an important
antimicrobial factor but is also known to promote pathogen infections by enhancing …

The phosphate modification of drugs is a common chemical strategy to increase solubility
and allow for parenteral administration. Unfortunately, phosphate modifications often elicit …

Keratinocytes (KCs) form the outer epithelial barrier of the body, protecting against invading
pathogens. Mice lacking the IL-17RA or both IL-17A and IL-17F develop spontaneous …

Staphylococcus aureus is a leading cause of bacteremia, further complicated by the
emergence of antibiotic-resistant strains such as methicillin-resistant S. aureus (MRSA). A …