The war on multidrug resistance (MDR) has resulted in the greatest loss to the world's
economy. Antibiotics, the bedrock, and wonder drug of the 20th century have played a …

Epithelial-to-Mesenchymal Transition (EMT) has been shown to be crucial in tumorigenesis
where the EMT program enhances metastasis, chemoresistance and tumor stemness. Due …

Despite the recent advances in the field of chemically synthetized pharmaceutical agents,
nature remains the main supplier of bioactive molecules. The research of natural products is …

Cisplatin and other platinum-based drugs, such as carboplatin, ormaplatin, and oxaliplatin,
have been widely used to treat a multitude of human cancers. However, a considerable …

Plant secondary metabolites (PSMs) are vital for human health and constitute the skeletal
framework of many pharmaceutical drugs. Indeed, more than 25% of the existing drugs …

A variety of organisms, such as bacteria, fungi, and plants, produce secondary metabolites,
also known as natural products. Natural products have been a prolific source and an …

Cancer is a multistage process resulting in an uncontrolled and abrupt division of cells and
is one of the leading causes of mortality. The cases reported and the predictions for the near …

Reactive oxygen species (ROS) induce carcinogenesis by causing genetic mutations,
activating oncogenes, and increasing oxidative stress, all of which affect cell proliferation …

Carvacrol (CV) is a phenolic monoterpenoid found in essential oils of oregano (Origanum
vulgare), thyme (Thymus vulgaris), pepperwort (Lepidium flavum), wild bergamot (Citrus …

This contribution is a completely updated and expanded version of the four prior analogous
reviews that were published in this journal in 1997, 2003, 2007, and 2012. In the case of all …