The molecular mechanisms and therapeutic strategies of EMT in tumor progression and metastasis
Y Huang, W Hong, X Wei - Journal of hematology & oncology, 2022 - Springer
Epithelial–mesenchymal transition (EMT) is an essential process in normal embryonic
development and tissue regeneration. However, aberrant reactivation of EMT is associated …
development and tissue regeneration. However, aberrant reactivation of EMT is associated …
Dynamic EMT: a multi‐tool for tumor progression
The process of epithelial–mesenchymal transition (EMT) is fundamental for embryonic
morphogenesis. Cells undergoing it lose epithelial characteristics and integrity, acquire …
morphogenesis. Cells undergoing it lose epithelial characteristics and integrity, acquire …
MicroRNA therapeutics: towards a new era for the management of cancer and other diseases
In just over two decades since the discovery of the first microRNA (miRNA), the field of
miRNA biology has expanded considerably. Insights into the roles of miRNAs in …
miRNA biology has expanded considerably. Insights into the roles of miRNAs in …
EMT, CSCs, and drug resistance: the mechanistic link and clinical implications
The success of anticancer therapy is usually limited by the development of drug resistance.
Such acquired resistance is driven, in part, by intratumoural heterogeneity—that is, the …
Such acquired resistance is driven, in part, by intratumoural heterogeneity—that is, the …
The role of hypoxia in the tumor microenvironment and development of cancer stem cell: a novel approach to develo** treatment
A Emami Nejad, S Najafgholian, A Rostami… - Cancer Cell …, 2021 - Springer
Hypoxia is a common feature of solid tumors, and develops because of the rapid growth of
the tumor that outstrips the oxygen supply, and impaired blood flow due to the formation of …
the tumor that outstrips the oxygen supply, and impaired blood flow due to the formation of …
Epithelial mesenchymal transition in tumor metastasis
V Mittal - Annual Review of Pathology: Mechanisms of Disease, 2018 - annualreviews.org
Metastasis is the major cause of cancer-related deaths; therefore, the prevention and
treatment of metastasis are fundamental to improving clinical outcomes. Epithelial …
treatment of metastasis are fundamental to improving clinical outcomes. Epithelial …
Epithelial-mesenchymal plasticity in cancer progression and metastasis
W Lu, Y Kang - Developmental cell, 2019 - cell.com
Epithelial-to-mesenchymal transition (EMT) and its reversed process, mesenchymal-to-
epithelial transition (MET), are fundamental processes in embryonic development and tissue …
epithelial transition (MET), are fundamental processes in embryonic development and tissue …
Regulatory networks defining EMT during cancer initiation and progression
Epithelial to mesenchymal transition (EMT) is essential for driving plasticity during
development, but is an unintentional behaviour of cells during cancer progression. The EMT …
development, but is an unintentional behaviour of cells during cancer progression. The EMT …
[HTML][HTML] Epithelial-mesenchymal transitions in development and disease
The epithelial to mesenchymal transition (EMT) plays crucial roles in the formation of the
body plan and in the differentiation of multiple tissues and organs. EMT also contributes to …
body plan and in the differentiation of multiple tissues and organs. EMT also contributes to …
[HTML][HTML] A long noncoding RNA activated by TGF-β promotes the invasion-metastasis cascade in hepatocellular carcinoma
The role of TGF-β-induced epithelial-mesenchymal transition (EMT) in cancer cell
dissemination is well established, but the involvement of lncRNAs in TGF-β signaling is still …
dissemination is well established, but the involvement of lncRNAs in TGF-β signaling is still …