Biochemistry and molecular biology of flaviviruses
Flaviviruses, such as dengue, Japanese encephalitis, tick-borne encephalitis, West Nile,
yellow fever, and Zika viruses, are critically important human pathogens that sicken a …
yellow fever, and Zika viruses, are critically important human pathogens that sicken a …
Ten years of dengue drug discovery: progress and prospects
To combat neglected diseases, the Novartis Institute of Tropical Diseases (NITD) was
founded in 2002 through private–public funding from Novartis and the Singapore Economic …
founded in 2002 through private–public funding from Novartis and the Singapore Economic …
The dengue virus NS5 protein as a target for drug discovery
The non-structural protein 5 (NS5) of flaviviruses is the most conserved amongst the viral
proteins. It is about 900 kDa and bears enzymatic activities that play vital roles in virus …
proteins. It is about 900 kDa and bears enzymatic activities that play vital roles in virus …
Zika virus methyltransferase: structure and functions for drug design perspectives
B Coutard, K Barral, J Lichiere, B Selisko… - Journal of …, 2017 - Am Soc Microbiol
ABSTRACT The Flavivirus Zika virus (ZIKV) is the causal agent of neurological disorders like
microcephaly in newborns or Guillain-Barre syndrome. Its NS5 protein embeds a …
microcephaly in newborns or Guillain-Barre syndrome. Its NS5 protein embeds a …
The crystal structure of Zika virus NS 5 reveals conserved drug targets
W Duan, H Song, H Wang, Y Chai, C Su, J Qi… - The EMBO …, 2017 - embopress.org
Zika virus (ZIKV) has emerged as major health concern, as ZIKV infection has been shown
to be associated with microcephaly, severe neurological disease and possibly male sterility …
to be associated with microcephaly, severe neurological disease and possibly male sterility …
Dengue virus nonstructural protein 5 (NS5) assembles into a dimer with a unique methyltransferase and polymerase interface
VJ Klema, M Ye, A Hindupur, T Teramoto… - PLoS …, 2016 - journals.plos.org
Flavivirus nonstructural protein 5 (NS5) consists of methyltransferase (MTase) and RNA-
dependent RNA polymerase (RdRp) domains, which catalyze 5'-RNA cap**/methylation …
dependent RNA polymerase (RdRp) domains, which catalyze 5'-RNA cap**/methylation …
[HTML][HTML] Functional RNA during Zika virus infection
Zika virus (ZIKV; family Flaviviridae; genus Flavivirus) is a pathogenic mosquito-borne RNA
virus that currently threatens human health in the Americas, large parts of Asia and …
virus that currently threatens human health in the Americas, large parts of Asia and …
Small molecule inhibitors that selectively block dengue virus methyltransferase
SP Lim, LS Sonntag, C Noble, SH Nilar, RH Ng… - Journal of Biological …, 2011 - ASBMB
Crystal structure analysis of Flavivirus methyltransferases uncovered a flavivirus-conserved
cavity located next to the binding site for its cofactor, S-adenosyl-methionine (SAM) …
cavity located next to the binding site for its cofactor, S-adenosyl-methionine (SAM) …
Dengue virus non-structural protein 5
The World Health Organization estimates that the yearly number of dengue cases averages
390 million. This mosquito-borne virus disease is endemic in over 100 countries and will …
390 million. This mosquito-borne virus disease is endemic in over 100 countries and will …
Innate immunity evasion by Dengue virus
For viruses to productively infect their hosts, they must evade or inhibit important elements of
the innate immune system, namely the type I interferon (IFN) response, which negatively …
the innate immune system, namely the type I interferon (IFN) response, which negatively …