Sickle cell anaemia (SCD) is a life-threatening haematological disorder which is
predominant in sub-Saharan Africa and is triggered by a genetic mutation of the β-chain …

Hereditary anemia has various manifestations, such as sickle cell disease (SCD), Fanconi
anemia, glucose-6-phosphate dehydrogenase deficiency (G6PDD), and thalassemia. The …

Sickle cell disease (SCD) is hallmarked by an underlying chronic inflammatory condition,
which is contributed by heme-activated proinflammatory macrophages. Although previous …

Sickle cell disease (SCD) is an inherited hemoglobinopathy that is caused by the presence
of abnormal hemoglobin S (HbS) in red blood cells, leading to alterations in red cell …

Monocytes are considered crucial actors of inflammation in sickle cell disease (SCD), being
responsible for an increased production of proinflammatory cytokines such as tumor …

The genetic and molecular basis of sickle cell disease (SCD) has long been characterized
but the pathophysiological basis has not been entirely defined. How a red cell hemolytic …

Sickle cell disease (SCD) is a common inherited clinical syndrome, characterized by the
presence of hemoglobin S. Anemia, susceptibility to infections and episodes of vaso …

This study aimed to comprehensively analyze inflammatory and autoimmune characteristics
of patients with sickle cell disease (SCD) at a steady-state condition (StSt) compared to …

The root cause of sickle cell disease (SCD) has been known for nearly a century, however,
few therapies to treat the disease are available. Over several decades of work, with …

Introduction: The mutation of the beta-globin gene that causes sickle cell disease (SCD)
results in pleiotropic effects, such as hemolysis and vaso-occlusive crisis that can induce …