Hallmarks of transcriptional intratumour heterogeneity across a thousand tumours

A Gavish, M Tyler, AC Greenwald, R Hoefflin, D Simkin… - Nature, 2023 - nature.com
Each tumour contains diverse cellular states that underlie intratumour heterogeneity (ITH), a
central challenge of cancer therapeutics. Dozens of recent studies have begun to describe …

Extracellular vesicles and transforming growth factor β signaling in cancer

DM Rodrigues-Junior, C Tsirigoti, SK Lim… - Frontiers in cell and …, 2022 - frontiersin.org
Complexity in mechanisms that drive cancer development and progression is exemplified by
the transforming growth factor β (TGF-β) signaling pathway, which suppresses early-stage …

[HTML][HTML] Landscape of extracellular vesicles in the tumour microenvironment: Interactions with stromal cells and with non-cell components, and impacts on metabolic …

DX Zhang, LT Vu, NN Ismail, MTN Le… - Seminars in cancer …, 2021 - Elsevier
Extracellular vesicles (EVs) are increasingly recognised as a pivotal player in cell-cell
communication, an attribute of EVs that derives from their ability to transport bioactive …

miR‐34a in extracellular vesicles from bone marrow mesenchymal stem cells reduces rheumatoid arthritis inflammation via the cyclin I/ATM/ATR/p53 axis

H Wu, X Zhou, X Wang, W Cheng, X Hu… - Journal of cellular …, 2021 - Wiley Online Library
Extracellular vesicles (Evs) participate in the development of rheumatoid arthritis (RA), but
the mechanisms remain unclear. This study aimed to determine the mechanism by which …

Extracellular vesicles and oncogenic signaling

A Schubert, M Boutros - Molecular oncology, 2021 - Wiley Online Library
In recent years, extracellular vesicles (EVs) emerged as potential diagnostic and prognostic
markers for cancer therapy. While the field of EV research is rapidly develo** and their …

[PDF][PDF] Role of extracellular vesicles in chronic lung disease

A Trappe, SC Donnelly, P McNally, JA Cop**er - Thorax, 2021 - thorax.bmj.com
To explore the role of extracellular vesicles (EVs) in chronic lung diseases. EVs are
emerging as mediators of intercellular communication and possible diagnostic markers of …

Improving extracellular vesicles visualization: From static to motion

P Reclusa, P Verstraelen, S Taverna… - Scientific reports, 2020 - nature.com
In the last decade, extracellular vesicles (EVs) have become a hot topic. The findings on EVs
content and effects have made them a major field of interest in cancer research. EVs, are …

microRNA‐19b‐3p‐containing extracellular vesicles derived from macrophages promote the development of atherosclerosis by targeting JAZF1

Q Wang, Y Dong, H Wang - Journal of cellular and molecular …, 2022 - Wiley Online Library
Atherosclerosis has been regarded as a major contributor to cardiovascular disease. The
role of extracellular vesicles (EVs) in the treatment of atherosclerosis has been increasingly …

Tumor-derived extracellular vesicles shuttle c-Myc to promote gastric cancer growth and metastasis via the KCNQ1OT1/miR-556-3p/CLIC1 axis

B Li, Y Chen, L Liang, Y Wang, W Huang, K Zhao… - Cell Death & …, 2022 - nature.com
Gastric cancer (GC) is a heterogeneous disease with poor prognosis. Tumor-derived
extracellular vesicles (EVs) assume a role in intercellular communication by carrying various …

A novel lncRNA MTAR1 promotes cancer development through IGF2BPs mediated post-transcriptional regulation of c-MYC

Y Gao, M Jiang, F Guo, X Liu, Q Zhang, S Yang… - Oncogene, 2022 - nature.com
Abnormal translation of the MYC proto-oncogene is a hallmark of the initiation and
maintenance of tumorigenesis. However, the molecular mechanism underlying increased …