Glioblastoma (GBM) is an incurable primary malignant brain cancer hallmarked with a
substantial protumorigenic immune component. Knowledge of the GBM immune …

DNA direct reversal repair (DRR) is unique in that no DNA synthesis is required to correct
the error and therefore repair via such mechanisms are error-free. In humans, DRR is …

Most orally administered drugs fail to reach the intracerebral regions because of the
intestinal epithelial barrier (IEB) and the blood–brain barrier (BBB), which are located …

Glioblastoma multiforme (GBM) is one of the most malignant cancers in human brain. The
prognosis of GBM is extremely poor because it is resistant to radiotherapy and …

Background The changes induced in host immunity and the tumor microenvironment by
chemotherapy have been shown to impact immunotherapy response in both a positive and …

The DNA damage response (DDR) and the blood-tumor barrier (BTB) restrict
chemotherapeutic success for primary brain tumors like glioblastomas (GBMs). Coherently …

Background The tumour microenvironment contributes to chemotherapy resistance in
gliomas, and glioma-associated mesenchymal stromal/stem cells (gaMSCs) are important …

The survival benefits of patients with glioblastoma (GBM) remain unsatisfactory due to the
intrinsic or acquired resistance to temozolomide (TMZ). We elucidated the mechanisms of …

Sulforaphane (SFN), an isothiocyanate (ITC) derived from cruciferous vegetables,
particularly broccoli and broccoli sprouts, has been widely investigated due to its promising …

Melanoma and other solid cancers are frequently resistant to chemotherapies based on
DNA alkylating agents such as dacarbazine and temozolomide. As a consequence, clinical …