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Memory B cells
Recent advances in studies of immune memory in mice and humans have reinforced the
concept that memory B cells play a critical role in protection against repeated infections …
concept that memory B cells play a critical role in protection against repeated infections …
B cell depletion therapies in autoimmune disease: advances and mechanistic insights
In the past 15 years, B cells have been rediscovered to be not merely bystanders but rather
active participants in autoimmune aetiology. This has been fuelled in part by the clinical …
active participants in autoimmune aetiology. This has been fuelled in part by the clinical …
Cell2location maps fine-grained cell types in spatial transcriptomics
Spatial transcriptomic technologies promise to resolve cellular wiring diagrams of tissues in
health and disease, but comprehensive map** of cell types in situ remains a challenge …
health and disease, but comprehensive map** of cell types in situ remains a challenge …
[HTML][HTML] Loss of Bcl-6-expressing T follicular helper cells and germinal centers in COVID-19
Humoral responses in coronavirus disease 2019 (COVID-19) are often of limited durability,
as seen with other human coronavirus epidemics. To address the underlying etiology, we …
as seen with other human coronavirus epidemics. To address the underlying etiology, we …
A blueprint for tumor-infiltrating B cells across human cancers
B lymphocytes are essential mediators of humoral immunity and play multiple roles in
human cancer. To decode the functions of tumor-infiltrating B cells, we generated a B cell …
human cancer. To decode the functions of tumor-infiltrating B cells, we generated a B cell …
Molecular map of chronic lymphocytic leukemia and its impact on outcome
Recent advances in cancer characterization have consistently revealed marked
heterogeneity, impeding the completion of integrated molecular and clinical maps for each …
heterogeneity, impeding the completion of integrated molecular and clinical maps for each …
Germinal center and extrafollicular B cell responses in vaccination, immunity, and autoimmunity
Activated B cells participate in either extrafollicular (EF) or germinal center (GC) responses.
Canonical responses are composed of a short wave of plasmablasts (PBs) arising from EF …
Canonical responses are composed of a short wave of plasmablasts (PBs) arising from EF …
In Vivo CD4+ T Cell Differentiation and Function: Revisiting the Th1/Th2 Paradigm
The discovery of CD4+ T cell subset–defining master transcription factors and framing of the
Th1/Th2 paradigm ignited the CD4+ T cell field. Advances in in vivo experimental systems …
Th1/Th2 paradigm ignited the CD4+ T cell field. Advances in in vivo experimental systems …
[HTML][HTML] CD4 T helper cell subsets and related human immunological disorders
The immune system plays a critical role in protecting hosts from the invasion of organisms.
CD4 T cells, as a key component of the immune system, are central in orchestrating adaptive …
CD4 T cells, as a key component of the immune system, are central in orchestrating adaptive …
Age-associated B cells in autoimmune diseases
Age-associated B cells (ABCs) are a transcriptionally and functionally unique B cell
population. In addition to arising with age and following infection, ABCs are expanded …
population. In addition to arising with age and following infection, ABCs are expanded …