Combining nanomedicine and immunotherapy

Y Shi, T Lammers - Accounts of chemical research, 2019 - ACS Publications
Conspectus Nanomedicine holds significant potential to improve the efficacy of cancer
immunotherapy. Thus far, nanomedicines, ie, 1–100 (0) nm sized drug delivery systems …

Nanoparticle design strategies for enhanced anticancer therapy by exploiting the tumour microenvironment

Y Dai, C Xu, X Sun, X Chen - Chemical Society Reviews, 2017 - pubs.rsc.org
Nanovehicles can efficiently carry and deliver anticancer agents to tumour sites. Compared
with normal tissue, the tumour microenvironment has some unique properties, such as …

Collagenase nanoparticles enhance the penetration of drugs into pancreatic tumors

A Zinger, L Koren, O Adir, M Poley, M Alyan, Z Yaari… - ACS …, 2019 - ACS Publications
Overexpressed extracellular matrix (ECM) in pancreatic ductal adenocarcinoma (PDAC)
limits drug penetration into the tumor and is associated with poor prognosis. Here, we …

Recent progress in development of siRNA delivery vehicles for cancer therapy

HJ Kim, A Kim, K Miyata, K Kataoka - Advanced drug delivery reviews, 2016 - Elsevier
Recent progress in RNA biology has broadened the scope of therapeutic targets of RNA
drugs for cancer therapy. However, RNA drugs, typically small interfering RNAs (siRNAs) …

Progress of drug-loaded polymeric micelles into clinical studies

H Cabral, K Kataoka - Journal of Controlled Release, 2014 - Elsevier
Targeting tumors with long-circulating nano-scaled carriers is a promising strategy for
systemic cancer treatment. Compared with free small therapeutic agents, nanocarriers can …

Calcium-based biomaterials for diagnosis, treatment, and theranostics

C Qi, J Lin, LH Fu, P Huang - Chemical Society Reviews, 2018 - pubs.rsc.org
Calcium-based (CaXs) biomaterials including calcium phosphates, calcium carbonates,
calcium silicate and calcium fluoride have been widely utilized in the biomedical field owing …

Biomolecule-assisted green synthesis of nanostructured calcium phosphates and their biomedical applications

C Qi, S Musetti, LH Fu, YJ Zhu, L Huang - Chemical Society Reviews, 2019 - pubs.rsc.org
Calcium phosphates (CaPs) are ubiquitous in nature and vertebrate bones and teeth, and
have high biocompatibility and promising applications in various biomedical fields …

The effect of nanoparticle uptake on cellular behavior: disrupting or enabling functions?

A Panariti, G Miserocchi, I Rivolta - Nanotechnology, science and …, 2012 - Taylor & Francis
Nanoparticles (NPs) are materials with overall dimensions in the nanoscale range. They
have unique physicochemical properties, and have emerged as important players in current …

Tumour microenvironment responsive nanoconstructs for cancer theranostic

A Gulzar, J Xu, C Wang, F He, D Yang, S Gai, P Yang… - Nano today, 2019 - Elsevier
The tumour mass is made up of not only of a heterogeneous population of cancer cells
nonetheless also a mixture of resident as well as the infiltrating host cells, secreted factors …

Enhancing endosomal escape for nanoparticle mediated siRNA delivery

D Ma - Nanoscale, 2014 - pubs.rsc.org
Gene therapy with siRNA is a promising biotechnology to treat cancer and other diseases.
To realize siRNA-based gene therapy, a safe and efficient delivery method is essential …