[HTML][HTML] Mass spectrometry imaging methods for visualizing tumor heterogeneity

KD Duncan, H Pětrošová, JJ Lum… - Current Opinion in …, 2024 - Elsevier
Highlights•Current strategies to map lipids, metabolites, and proteins in tumor
tissues.•Recent biological insights obtained from MSI of tumor samples.•Challenges in …

From big data to big insights: statistical and bioinformatic approaches for exploring the lipidome

JR Chappel, KI Kirkwood-Donelson, DM Reif… - Analytical and …, 2024 - Springer
The goal of lipidomic studies is to provide a broad characterization of cellular lipids present
and changing in a sample of interest. Recent lipidomic research has significantly contributed …

Streamlining Phenotype Classification and Highlighting Feature Candidates: A Screening Method for Non-Targeted Ion Mobility Spectrometry-Mass Spectrometry (IMS …

JR Chappel, KI Kirkwood-Donelson, JN Dodds… - Analytical …, 2024 - ACS Publications
Nontargeted analysis (NTA) is increasingly utilized for its ability to identify key molecular
features beyond known targets in complex samples. NTA is particularly advantageous in …

Desorption Electrospray Ionization Mass Spectrometry Imaging Techniques Depict a Reprogramming of Energy and Purine Metabolism in the Core Brain Regions of …

Y Song, F **ao, J Aa, G Wang - Metabolites, 2024 - mdpi.com
Depression is associated with pathological changes and metabolic abnormalities in multiple
brain regions. The simultaneous comprehensive and in situ detection of endogenous …