In malaria, hemozoin (Hz) is released during erythrocyte rupture, and subsequent
phagocytosis appears to cause important immune-modulatory effects. Hz obtained from …

The side-chains of quinoline antimalarial agents are the major concern of focus to build
novel and efficaciaous bioactive and clinical antimalarials. Bioative antimalarial analogs …

Many research institutions, clinical diagnostic laboratories, and blood banks are desperately
searching for a possibility to identify and quantify heme in different physiological and …

Background Justicia insularis (Acanthaceae) T. Anderson is ethnopharmacologically used in
Nigeria for the treatment of diseases including malaria. Therefore, this study was designed …

Aims: Early phagocytosis of glucose-6-phosphate dehydrogenase (G6PD)-deficient
erythrocytes parasitized by Plasmodium falciparum were shown to protect G6PD-deficient …

Plasmodione (PD) is a potent antimalarial redox-active drug acting at low nM range
concentrations on different malaria parasite stages. In this study, in order to determine the …

Endoperoxides are a class of compounds, which is well-known for their antimalarial
properties, but few reports exist about 3, 5-disubstituted 1, 2-dioxolanes. After having …

Improved methodological tools to hasten antimalarial drug discovery remain of interest,
especially when considering natural products as a source of drug candidates. We propose a …

Three novel tracers designed as fluorescent surrogates of artemisinin-derived antimalarial
drugs (ie, dihydroartemisinin, artemether, arteether, and artemisone) were synthesized from …

A library of 33 polymethoxylated flavones (PMF) was evaluated for heme-binding affinity by
biomimetic MS assay and in vitro antiplasmodial activity on two strains of P. falciparum …