The property of mixed selectivity has been discussed at a computational level and offers a
strategy to maximize computational power by adding versatility to the functional role of each …

The prefrontal cortex (PFC) orchestrates higher brain function and becomes disrupted in
many mental health disorders. The rodent medial PFC (mPFC) possesses an enormous …

Dopamine (DA) plays multiple roles in a wide range of physiological and pathological
processes via a large network of dopaminergic projections. To dissect the spatiotemporal …

Cognitive control, the ability to orchestrate behavior in accord with our goals, depends on
the prefrontal cortex. These cognitive functions are heavily influenced by the …

Downward social mobility is a well-known mental risk factor for depression, but its neural
mechanism remains elusive. Here, by forcing mice to lose against their subordinates in a …

Emotion recognition and the resulting responses are important for survival and social
functioning. However, how socially derived information is processed for reliable emotion …

Naturalistic observations show that decisions to avoid or escape predators occur at different
spatiotemporal scales and that they are supported by different computations and neural …

There is disagreement on how best to define and investigate fear. Nature Neuroscience
asked Dean Mobbs to lead experts from the fields of human and animal affective …

Midbrain dopamine signals are widely thought to report reward prediction errors that drive
learning in the basal ganglia. However, dopamine has also been implicated in various …

The medial prefrontal cortex (mPFC) and its abundant connections with other brain regions
play key roles in memory, cognition, decision making, social behaviors, and mood …