The elongation stage of transcription by RNA polymerase II (RNA Pol II) is central to the
regulation of gene expression in response to developmental and environmental cues in …

According to the Geroscience concept that organismal aging and age-associated diseases
share the same basic molecular mechanisms, the identification of biomarkers of age that can …

Aging is characterized by the accumulation of proteins that display amyloid-like behavior.
However, the molecular mechanisms by which these proteins arise remain unclear. Here …

Histones are integral components of eukaryotic chromatin that have a pivotal role in the
organization and function of the genome. The dynamic regulation of chromatin involves the …

The proper maintenance of mRNA quality that is regulated by diverse surveillance pathways
is essential for cellular homeostasis and is highly conserved among eukaryotes. Here, we …

Gallium-based liquid metal (LM) exhibits exceptional properties such as high conductivity
and biocompatibility, rendering it highly valuable for the development of conformal …

Alternative transcription start site usage (ATSS) is a widespread regulatory strategy that
enables genes to choose between multiple genomic loci for initiating transcription. This …

Two recent studies, coauthored by us, reported age-associated increase in transcriptional
stress due to elevated stalling of RNA polymerases and accelerated transcription …

We are facing a growing aging population, along with increasing pressure on health
systems, caused by the impact of chronic co‐morbidities (ie cancer, cardiovascular and …

Senescence and epigenetic alterations stand out as two well-characterized hallmarks of
aging. When cells become senescent, they cease proliferation and release inflammatory …