Knee osteoarthritis: a review of pathogenesis and state-of-the-art non-operative therapeutic considerations

D Primorac, V Molnar, E Rod, Ž Jeleč, F Čukelj… - Genes, 2020 - mdpi.com
Being the most common musculoskeletal progressive condition, osteoarthritis is an
interesting target for research. It is estimated that the prevalence of knee osteoarthritis (OA) …

Benefits and mechanisms of exercise training for knee osteoarthritis

CY Zeng, ZR Zhang, ZM Tang, FZ Hua - Frontiers in physiology, 2021 - frontiersin.org
Knee osteoarthritis is a chronic degenerative disease. Cartilage and subchondral bone
degeneration, as well as synovitis, are the main pathological changes associated with knee …

Cartilage tissue engineering: From proinflammatory and anti‑inflammatory cytokines to osteoarthritis treatments

S Liu, Z Deng, K Chen, S Jian… - Molecular …, 2022 - spandidos-publications.com
Osteoarthritis (OA), one of the most common joint diseases, is characterized by fibrosis,
rhagadia, ulcers and attrition of articular cartilage due to a number of factors. The etiology of …

[HTML][HTML] ROS/oxidative stress signaling in osteoarthritis

P Lepetsos, AG Papavassiliou - … et Biophysica Acta (BBA)-Molecular Basis …, 2016 - Elsevier
Osteoarthritis is the most common joint disorder with increasing prevalence due to aging of
the population. Its multi-factorial etiology includes oxidative stress and the overproduction of …

Quercetin alleviates rat osteoarthritis by inhibiting inflammation and apoptosis of chondrocytes, modulating synovial macrophages polarization to M2 macrophages

Y Hu, Z Gui, Y Zhou, L **a, K Lin, Y Xu - Free Radical Biology and …, 2019 - Elsevier
Osteoarthritis (OA) is a progressive joint disorder that is primarily characterized by the
degeneration and destruction of the articular cartilage. Cartilage matrix degradation …

Animal models of osteoarthritis: classification, update, and measurement of outcomes

EL Kuyinu, G Narayanan, LS Nair… - Journal of orthopaedic …, 2016 - Springer
Osteoarthritis (OA) is one of the most commonly occurring forms of arthritis in the world
today. It is a debilitating chronic illness causing pain and immense discomfort to the affected …

Artemisinin relieves osteoarthritis by activating mitochondrial autophagy through reducing TNFSF11 expression and inhibiting PI3K/AKT/mTOR signaling in cartilage

J Li, M Jiang, Z Yu, C **ong, J Pan, Z Cai, N Xu… - Cellular & molecular …, 2022 - Springer
Osteoarthritis (OA) is a widespread chronic degenerative joint disease characterized by the
degeneration of articular cartilage or inflamed joints. Our findings indicated that treatment …

The potential role of synovial cells in the progression and treatment of osteoarthritis

Z Zou, H Li, K Yu, K Ma, Q Wang, J Tang, G Liu… - …, 2023 - Wiley Online Library
Osteoarthritis (OA), the commonest arthritis, is characterized by the progressive destruction
of cartilage, leading to disability. The Current early clinical treatment strategy for OA often …

Effects of GH/IGF axis on bone and cartilage

M Dixit, SB Poudel, S Yakar - Molecular and cellular endocrinology, 2021 - Elsevier
Growth hormone (GH) and its mediator, the insulin-like growth factor-1 (IGF-1) regulate
somatic growth, metabolism and many aspects of aging. As such, actions of GH/IGF have …

HIF-1α in osteoarthritis: from pathogenesis to therapeutic implications

CY Zeng, XF Wang, FZ Hua - Frontiers in Pharmacology, 2022 - frontiersin.org
Osteoarthritis is a common age-related joint degenerative disease. Pain, swelling, brief
morning stiffness, and functional limitations are its main characteristics. There are still no …