Nanomedicine and drug delivery systems in cancer and regenerative medicine

E Garbayo, S Pascual‐Gil… - Wiley …, 2020 - Wiley Online Library
Nanomedicine and drug delivery technologies play a prominent role in modern medicine,
facilitating better treatments than conventional drugs. Nanomedicine is being increasingly …

Advanced strategies for modulation of the material–macrophage interface

L Davenport Huyer, S Pascual‐Gil… - Advanced Functional …, 2020 - Wiley Online Library
Biomaterials are becoming increasingly crucial for healthcare solutions, with extensive use
in the field of tissue engineering and drug delivery. After implantation, biomaterials trigger an …

[HTML][HTML] Mesenchymal stem cell-derived exosomes reduce A1 astrocytes via downregulation of phosphorylated NFκB P65 subunit in spinal cord injury

L Wang, S Pei, L Han, B Guo, Y Li, R Duan… - Cellular Physiology and …, 2018 - karger.com
Background/Aims: Neurotoxic A1 astrocytes are induced by inflammation after spinal cord
injury (SCI), and the inflammation-related Nuclear Factor Kappa B (NFκB) pathway may be …

Cysteine-based redox-responsive nanoparticles for fibroblast-targeted drug delivery in the treatment of myocardial infarction

X Ji, Y Meng, Q Wang, T Tong, Z Liu, J Lin, B Li, Y Wei… - ACS …, 2023 - ACS Publications
Upon myocardial infarction (MI), activated cardiac fibroblasts (CFs) begin to remodel the
myocardium, leading to cardiac fibrosis and even heart failure. No therapeutic approaches …

Exosome therapeutics for lung regenerative medicine

K Popowski, H Lutz, S Hu, A George… - Journal of …, 2020 - Taylor & Francis
Exosomes are 30 to 100 nm extracellular vesicles that are secreted by many cell types.
Initially viewed as cellular garbage with no biological functions, exosomes are now …

Nasal drug delivery of anticancer drugs for the treatment of glioblastoma: preclinical and clinical trials

FA Bruinsmann, G Richter Vaz… - Molecules, 2019 - mdpi.com
Glioblastoma (GBM) is the most lethal form of brain tumor, being characterized by the rapid
growth and invasion of the surrounding tissue. The current standard treatment for …

Nanoparticle-mediated drug delivery for treatment of ischemic heart disease

C Fan, J Joshi, F Li, B Xu, M Khan, J Yang… - … in bioengineering and …, 2020 - frontiersin.org
The regenerative capacity of an adult cardiac tissue is insufficient to repair the massive loss
of heart tissue, particularly cardiomyocytes (CMs), following ischemia or other catastrophic …

[HTML][HTML] Cardiac tissue engineering for myocardial infarction treatment

P Gil-Cabrerizo, I Scacchetti, E Garbayo… - European Journal of …, 2023 - Elsevier
Myocardial infarction is one of the major causes of morbidity and mortality worldwide.
Current treatments can relieve the symptoms of myocardial ischemia but cannot repair the …

Micro-and nanotechnology approaches to improve Parkinson's disease therapy

PV Torres-Ortega, L Saludas, AS Hanafy… - Journal of controlled …, 2019 - Elsevier
Current therapies for Parkinson's disease are symptomatic and unable to regenerate the
brain tissue. In recent years, the therapeutic potential of a wide variety of neuroprotective …

[HTML][HTML] Polymeric nanoparticles in the diagnosis and treatment of myocardial infarction: Challenges and future prospects

M Karam, D Fahs, B Maatouk, B Safi, AA Jaffa… - Materials Today Bio, 2022 - Elsevier
Myocardial infarction (MI) is the leading cause of morbidity and mortality worldwide. Despite
extensive efforts to provide early diagnosis and adequate treatment regimens, detection of …