The advent of genome editing has transformed the therapeutic landscape for several
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …

Cancer is the second worldwide cause of death, exceeded only by cardiovascular diseases.
It is characterized by uncontrolled cell proliferation and an absence of cell death that, except …

Since the elucidation of the molecular structure of nucleic acids and understanding of their
role in encoding and translating genetic information into biological function, 1 the knowledge …

This review focuses on the smart chemistry that has been utilized in develo** polymer-
based drug delivery systems over the past 10 years. We provide a comprehensive overview …

While knowledge of the composition and mode of action of bee and wasp venoms dates
back 50 years, the therapeutic value of these toxins remains relatively unexploded. The …

Small interfering RNAs (siRNAs) acting via RNA interference mechanisms are able to
recognize a homologous mRNA sequence in the cell and induce its degradation. The main …

Materials which respond to biological cues are the subject of intense research interest due
to their possible application in smart drug delivery vehicles. In particular, novel polymers …

Cell penetrating peptides (CPPs) can deliver cell-impermeable therapeutic cargos into cells.
In particular, CPP-cargo conjugates tend to accumulate inside cells by endocytosis …

Multiple extra-and intracellular obstacles, including low stability in blood, poor cellular
uptake, and inefficient endosomal escape and disassembly in the cytoplasm, have to be …

Gene therapy offers great opportunities for the treatment of severe diseases including
cancer. In recent years the design of synthetic carriers for nucleic acid delivery has become …