Multiple endocrine neoplasia type 1 (MEN1), a rare tumor syndrome that is inherited in an
autosomal dominant pattern, is continuing to raise great interest for endocrinology …

Gastroenteropancreatic (GEP) neuroendocrine tumours (NETs) are fairly rare neoplasms
that present many clinical challenges. They secrete peptides and neuroamines that cause …

Pluripotent embryonic stem cells (ESC s) are characterized by distinct epigenetic features
including a relative enrichment of histone modifications related to active chromatin. Among …

Pancreatic endocrine tumors (PETs) have long fascinated clini-cians, because some can
release biologically active hormones that cause distinct syndromes and provide important …

Recent data suggest an increase in the overall incidence of parathyroid disorders, with
primary hyperparathyroidism (PHPT) being the most prevalent parathyroid disorder. PHPT is …

Histone modifications influence the interactions of transcriptional regulators with chromatin.
Studies in embryos and embryonic stem (ES) cells have uncovered histone modification …

Menin, the product of the Men1 gene mutated in familial multiple endocrine neoplasia type 1
(MEN1), regulates transcription in differentiated cells. Menin associates with and modulates …

Abstract A National Cancer Institute summit meeting on gastroenteropancreatic
neuroendocrine and carcinoid tumors was held in September 2007 to present the currently …

Six multiple endocrine neoplasia (MEN) syndromes have received a level of attention that
might seem disproportionate to their low prevalence. The attention has been given because …

The Cre/loxP recombinase system for performing conditional gene targeting experiments
has been very useful in exploring genetic pathways that control both the development and …