Computational models in cardiology

SA Niederer, J Lumens, NA Trayanova - Nature reviews cardiology, 2019 - nature.com
The treatment of individual patients in cardiology practice increasingly relies on advanced
imaging, genetic screening and devices. As the amount of imaging and other diagnostic …

Precision medicine in human heart modeling: perspectives, challenges, and opportunities

M Peirlinck, FS Costabal, J Yao, JM Guccione… - … and modeling in …, 2021 - Springer
Precision medicine is a new frontier in healthcare that uses scientific methods to customize
medical treatment to the individual genes, anatomy, physiology, and lifestyle of each person …

The 'Digital Twin'to enable the vision of precision cardiology

J Corral-Acero, F Margara, M Marciniak… - European heart …, 2020 - academic.oup.com
Providing therapies tailored to each patient is the vision of precision medicine, enabled by
the increasing ability to capture extensive data about individual patients. In this position …

The openCARP simulation environment for cardiac electrophysiology

G Plank, A Loewe, A Neic, C Augustin… - Computer methods and …, 2021 - Elsevier
Abstract Background and Objective: Cardiac electrophysiology is a medical specialty with a
long and rich tradition of computational modeling. Nevertheless, no community standard for …

[HTML][HTML] A framework for the generation of digital twins of cardiac electrophysiology from clinical 12-leads ECGs

K Gillette, MAF Gsell, AJ Prassl, E Karabelas… - Medical image …, 2021 - Elsevier
Abstract Cardiac digital twins (Cardiac Digital Twin (CDT) s) of human electrophysiology
(Electrophysiology (EP)) are digital replicas of patient hearts derived from clinical data that …

Computationally guided personalized targeted ablation of persistent atrial fibrillation

PM Boyle, T Zghaib, S Zahid, RL Ali, D Deng… - Nature biomedical …, 2019 - nature.com
Atrial fibrillation (AF)—the most common arrhythmia—significantly increases the risk of
stroke and heart failure. Although catheter ablation can restore normal heart rhythms …

Integrated heart—coupling multiscale and multiphysics models for the simulation of the cardiac function

A Quarteroni, T Lassila, S Rossi… - Computer Methods in …, 2017 - Elsevier
Mathematical modeling of the human heart and its function can expand our understanding of
various cardiac diseases, which remain the most common cause of death in the developed …

The cardiovascular system: mathematical modelling, numerical algorithms and clinical applications

A Quarteroni, A Manzoni, C Vergara - Acta Numerica, 2017 - cambridge.org
Mathematical and numerical modelling of the cardiovascular system is a research topic that
has attracted remarkable interest from the mathematical community because of its intrinsic …

Modeling cardiac muscle fibers in ventricular and atrial electrophysiology simulations

R Piersanti, PC Africa, M Fedele, C Vergara… - Computer Methods in …, 2021 - Elsevier
Since myocardial fibers drive the electric signal propagation throughout the myocardium,
accurately modeling their arrangement is essential for simulating heart electrophysiology …

[HTML][HTML] Electro-mechanical whole-heart digital twins: a fully coupled multi-physics approach

T Gerach, S Schuler, J Fröhlich, L Lindner… - Mathematics, 2021 - mdpi.com
Mathematical models of the human heart are evolving to become a cornerstone of precision
medicine and support clinical decision making by providing a powerful tool to understand …