Today's biomanufacturing processes are still operated based on experience, and thus can
hardly cope with increasing bioprocess complexity. Recently, there is a growing interest in …

The production of monoclonal antibodies (mAbs) using Chinese Hamster Ovary (CHO) cells
has revolutionized the treatment of numerous diseases, solidifying their position as a …

In this work, we aim to introduce the concept of the degree of hybridization for cell culture
process modeling. We propose that a family of hybrid models can be created with varying …

The production of therapeutic proteins in mammalian cell culture is an essential unit
operation in biopharmaceutical manufacture that can benefit from the predictive insights of …

Despite the attempts that have started since the 1960s, not even a single cell line of marine
molluscs is available. Considering the vast contribution of marine bivalve aquaculture to the …

Over the past decades, virus‐like particle (VLP)‐based gene therapy (GT) evolved as a
promising approach to cure inherited diseases or cancer. Tremendous costs due to …

With a high required dosing and relatively low process efficiency, providing recombinant
adeno-associated virus (rAAV) supply for clinical trials and commercial demand remains …

Fed-batch cell culture is widely used in the biopharmaceutical industry to manufacture life-
saving therapeutics. Biopharmaceutical manufacturing processes can be variable due to the …

The optimization of animal feeds and cell culture media are problems of interest to a wide
range of industries and scientific disciplines. Both problems are dictated by the properties of …

Process intensification aims to increase productivity in biologics manufacturing. Significant
progress has been made in academia, the biopharmaceutical industry, and by the regulatory …