Recognition of phenotypic variability in pediatric asthma allows for a more personalized
therapeutic approach. Knowledge of the underlying pathophysiological and molecular …

The application of large-scale metabolomic profiling provides new opportunities for realizing
the potential of omics-based precision medicine for asthma. By leveraging data from over …

Acute respiratory distress syndrome (ARDS) is a life-threatening lung condition that arises
from multiple causes, including sepsis, pneumonia, trauma, and severe coronavirus disease …

Background: Although inhaled corticosteroids (ICS) are the first-line therapy for patients with
persistent asthma, many patients continue to have exacerbations. We developed machine …

Asthma is a chronic respiratory disease that affects 339 million people worldwide and has a
considerable impact on the pediatric population. Asthma symptoms can be controlled by …

Rationale Substantial variability in response to asthma treatment with inhaled corticosteroids
(ICS) has been described among individuals and populations, suggesting the contribution of …

Pediatric obesity-related asthma is characterized by non-atopic T helper 1 (Th1)
inflammation and steroid resistance. CDC42 upregulation in CD4+ T cells underlies Th1 …

Glucocorticoid drugs are commonly used in the treatment of several conditions, including
autoimmune diseases, asthma and cancer. Despite their widespread use and knowledge of …

F-box and leucine-rich repeat protein 7 (FBXL7), an F-box protein responsible for substrate
recognition by the SKP1-Cullin-1-F-box (SCF) ubiquitin ligases, plays an emerging role in …

Inhaled corticosteroids (ICS) are efficacious in the treatment of asthma, which affects more
than 300 million people in the world. While genome-wide association studies have identified …