Colorectal cancer (CRC) is among the most lethal and prevalent malignancies in the world
and was responsible for nearly 881,000 cancer-related deaths in 2018. Surgery and …

Colorectal cancer (CRC) accounts for about 10% of all new cancer cases globally. Located
at close proximity to the colorectal epithelium, the gut microbiota comprises a large …

BACKGROUND Humans ingest a multitude of small molecules that are foreign to the body
(xenobiotics), including dietary components, environmental chemicals, and …

The microbiota is composed of commensal bacteria and other microorganisms that live on
the epithelial barriers of the host. The commensal microbiota is important for the health and …

Advances in our understanding of how the gut microbiota contributes to human health and
diseases have expanded our insight into how microbial composition and function affect the …

Evidence is growing that the gut microbiota modulates the host response to
chemotherapeutic drugs, with three main clinical outcomes: facilitation of drug efficacy; …

Answer questions and earn CME/CNE The human body harbors enormous numbers of
microbiota that influence cancer susceptibility, in part through their prodigious metabolic …

Although the importance of human genetic polymorphisms in therapeutic outcomes is well
established, the role of our'second genome'(the microbiome) has been largely overlooked …

The gut microbiota has both direct and indirect effects on drug and xenobiotic metabolisms,
and this can have consequences for both efficacy and toxicity. Indeed, microbiome-driven …

The human gut microbiome modulates many host processes, including metabolism,
inflammation, and immune and cellular responses. It is becoming increasingly apparent that …