A review of gut microbiota‐derived metabolites in tumor progression and cancer therapy

Q Yang, B Wang, Q Zheng, H Li, X Meng… - Advanced …, 2023 - Wiley Online Library
Gut microbiota‐derived metabolites are key hubs connecting the gut microbiome and cancer
progression, primarily by remodeling the tumor microenvironment and regulating key …

Comprehensive review of targeted therapy for colorectal cancer

YH **e, YX Chen, JY Fang - Signal transduction and targeted therapy, 2020 - nature.com
Colorectal cancer (CRC) is among the most lethal and prevalent malignancies in the world
and was responsible for nearly 881,000 cancer-related deaths in 2018. Surgery and …

Gut microbiota in colorectal cancer: mechanisms of action and clinical applications

SH Wong, J Yu - Nature reviews Gastroenterology & hepatology, 2019 - nature.com
Colorectal cancer (CRC) accounts for about 10% of all new cancer cases globally. Located
at close proximity to the colorectal epithelium, the gut microbiota comprises a large …

Human gut microbiota and drug metabolism

A Pant, TK Maiti, D Mahajan, B Das - Microbial Ecology, 2023 - Springer
The efficacy of drugs widely varies in individuals, and the gut microbiota plays an important
role in this variability. The commensal microbiota living in the human gut encodes several …

Gut microbial beta-glucuronidase: a vital regulator in female estrogen metabolism

S Hu, Q Ding, W Zhang, M Kang, J Ma, L Zhao - Gut Microbes, 2023 - Taylor & Francis
ABSTRACT A growing amount of evidence has supported that gut microbiota plays a vital
role in the reproductive endocrine system throughout a woman's whole life, and gut …

Dietary metabolism, the gut microbiome, and heart failure

WHW Tang, DY Li, SL Hazen - Nature Reviews Cardiology, 2019 - nature.com
Advances in our understanding of how the gut microbiota contributes to human health and
diseases have expanded our insight into how microbial composition and function affect the …

Chemical transformation of xenobiotics by the human gut microbiota

N Koppel, V Maini Rekdal, EP Balskus - Science, 2017 - science.org
BACKGROUND Humans ingest a multitude of small molecules that are foreign to the body
(xenobiotics), including dietary components, environmental chemicals, and …

The mutual interplay of gut microbiota, diet and human disease

P Illiano, R Brambilla, C Parolini - The FEBS journal, 2020 - Wiley Online Library
The intestinal milieu harbours the gut microbiota, consisting of a complex community of
bacteria, archaea, fungi, viruses and protozoans that bring to the host organism an …

Microbiota: a key orchestrator of cancer therapy

S Roy, G Trinchieri - Nature Reviews Cancer, 2017 - nature.com
The microbiota is composed of commensal bacteria and other microorganisms that live on
the epithelial barriers of the host. The commensal microbiota is important for the health and …

Gut microbiota modulation of chemotherapy efficacy and toxicity

JL Alexander, ID Wilson, J Teare, JR Marchesi… - Nature reviews …, 2017 - nature.com
Evidence is growing that the gut microbiota modulates the host response to
chemotherapeutic drugs, with three main clinical outcomes: facilitation of drug efficacy; …