The molecular hybridization approach has been used to develop compounds with improved
efficacy by combining two or more pharmacophores of bioactive scaffolds. In this context …

Tuberculosis (TB), an infectious disease caused by the bacterium Mycobacterium
tuberculosis, was the leading cause of mortality worldwide in 2019 due to a single infectious …

Mycobacterium tuberculosis kills more people than any other bacterial pathogen and is
becoming increasingly untreatable due to the emergence of resistance. Verapamil, an FDA …

Numerous studies show efflux as a universal bacterial mechanism contributing to antibiotic
resistance and also that the activity of the antibiotics subject to efflux can be enhanced by …

Despite the efficacy of antibiotics to protect humankind against many deadly pathogens,
such as Mycobacterium tuberculosis, nothing can prevent the emergence of drug-resistant …

Mycobacterium tuberculosis (M. tb) has the extraordinary ability to adapt to the
administration of antibiotics through the development of resistance mechanisms. By rapidly …

Introduction Several decades of antitubercular drug discovery efforts have focused on novel
antitubercular chemotherapies. However, recent efforts have greatly shifted toward …

In this study, we have designed and synthesized pyrazoline analogues that partially mimic
the structure of mycobactin, to address the requirement of novel therapeutics to tackle the …

Highlights•Efflux pumps are membrane proteins involved in the transport of antimicrobial
drugs.•Inhibition of efflux systems can prevent drug resistance.•Strategies to avoid …

Considering the extensive evolutionary history of Mycobacterium tuberculosis, anti-
Tuberculosis (TB) drug therapy exerts a recent selective pressure. However, in a …