All organisms must sense and respond to their external environments, and this signal
transduction often involves second messengers such as cyclic nucleotides. One such …

Melatonin, a hormone secreted by the pineal gland, works directly and indirectly as a free
radical scavenger. Its other physiological or pharmacological activities could be dependent …

Cyclic AMP (cAMP) is an important signalling molecule across evolution, but its role in
malaria parasites is poorly understood. We have investigated the role of cAMP in asexual …

In obesity and diabetes, intramuscular fat (IMF) content correlates markedly with insulin
sensitivity, which makes IMF manipulation an area of therapeutic interest. Melatonin, an …

The cyclic nucleotides 3′, 5′-cyclic adenosine monophosphate (cAMP) and 3′, 5′-
cyclic guanosine monophosphate (cGMP) are intracellular messengers found in most …

Discovering the mechanisms by which cell signaling controls the cell cycle of the human
malaria parasite Plasmodium falciparum is fundamental to designing more effective …

Cyclic nucleotide signalling is a major regulator of malaria parasite differentiation.
Phosphodiesterase (PDE) enzymes are known to control cyclic GMP (cGMP) levels in the …

Phytomelatonin is a small multifunctional molecule found ubiquitously in plants, which plays
an important role in plant growth, development, and biotic and abiotic stress responses. The …

Apicomplexa encompasses a large number of intracellular parasites infecting a wide range
of animals. Cyclic nucleotide signaling is crucial for a variety of apicomplexan life stages and …

Indole compounds are involved in a range of functions in many organisms. In the human
malaria parasite Plasmodium falciparum, melatonin and other tryptophan derivatives are …