The use of proteins as therapeutics has a long history and is becoming ever more common
in modern medicine. While the number of protein-based drugs is growing every year …

Protein lipid modification involves the attachment of hydrophobic groups to proteins via
ester, thioester, amide, or thioether linkages. In this review, the specific click chemical …

Protein prenylation is a ubiquitous covalent post-translational modification found in all
eukaryotic cells, comprising attachment of either a farnesyl or a geranylgeranyl isoprenoid. It …

Creating covalent protein conjugates is an active area of research due to the wide range of
uses for protein conjugates spanning everything from biological studies to protein …

The biosynthesis of isopentenyl diphosphate (IPP) from either the mevalonate (MVA) or the
1-deoxy-d-xylulose 5-phosphate (DXP) pathway provides the key metabolite for primary and …

a-Factor from Saccharomyces cerevisiae is a farnesylated dodecapeptide involved in
mating. The molecule binds to a G-protein coupled receptor and hence serves as a simple …

Isoprenylation is a post-translational modification that increases protein hydrophobicity and
helps target certain proteins to membranes. Ras converting enzyme 1 (Rce1p) is an …

Site-selective protein modification is of utmost importance for many applications from
fundamental biology (fluorescent tagging) to therapeutic development (antibody-drug …

Multiple myeloma is a bone marrow cancer and is responsible for the death of approximately
12,000 people yearly in the United States. Multiple myeloma is the second most common …

Since its development as a strategy to study biological systems, click chemistry has found its
widespread use as a chemical tool in the discovery of post-translationally modified (PTM) …