The motor signs of Parkinson's disease are thought to result in large part from a reduction of
the level of dopamine in the basal ganglia. Over the last few years, many of the functional …

Purpose: A significant number of patients with epilepsy remain poorly controlled despite
antiepileptic medication (AED) treatment and are not eligible for resective surgery. Novel …

Quantitative magnetic susceptibility map** (QSM) has recently been introduced to provide
a novel quantitative and local MRI contrast. However, the anatomical contrast represented …

Microelectrode recording methods for stereotactic localization of the subthalamic nucleus
(STN) and surrounding structures are described. These methods accurately define targets …

Objective: To examine objectively the clinical effects of subthalamic nucleus (STN) deep
brain stimulation (DBS) in advanced PD. Methods: Our initial seven consecutive patients …

Neurosurgical treatment of Parkinson's disease (PD) frequently employs chronic high-
frequency deep brain stimulation (DBS) within the internal segment of globus pallidus (GPi) …

The aim of this study was to examine possible neuropsychological changes in patients with
advanced idiopathic Parkinson's disease treated with bilateral deep brain stimulation (DBS) …

Single-cell recording of the subthalamic nucleus (STN) was undertaken in 14 patients with
Parkinson's disease submitted to surgery. Three hundred and fifty neurones were recorded …

The major motor disturbances in Parkinson's disease are thought to be caused by
overactivity of the internal segment of the globus pallidus (GPi), in large part due to …

This review is part of the series on the clinical neurophysiology of movement disorders. It
focuses on Parkinson's disease and parkinsonism. The topics covered include the …