Background The diagnosis of rare genetic diseases is often challenging due to the
complexity of the genetic underpinnings of these conditions and the limited availability of …

Neural tube defects (NTDs) are the second most common congenital malformations of
humans, characterized by impaired development of the central nervous system. Even …

Orofacial clefts, including cleft lip and palate (CL/P) and neural tube defects (NTDs) are
among the most common congenital anomalies, but knowledge of the genetic basis of these …

Neural tube defects (NTDs) are serious congenital deformities of the nervous system that
occur owing to the failure of normal neural tube closures. Genetic and non-genetic factors …

Neural tube closure defect pathomechanisms in human embryonic development are poorly
understood. Here we identified spina bifida patients expressing novel variants of the …

Neural tube defects (NTDs) remain among the most common congenital anomalies.
Contributing risk factors include genetics and nutrient deficiencies, however, a …

Radiocarbon dating is the gold standard in archeology to estimate the age of skeletons, a
key to studying their origins. Many published ancient genomes lack reliable and direct dates …

Abstract Background Neural tube defects (NTDs) remain among the most common
congenital anomalies. Contributing risk factors include genetics and nutrient deficiencies …

Background: The diagnosis of rare genetic diseases is often challenging due to the
complexity of the genetic underpinnings of these conditions and the limited availability of …

Neural organoids have revolutionized how human neurodevelopmental disorders (NDDs)
are studied. Yet, their utility for screening complex NDD etiologies and in drug discovery is …