Highly active antiretroviral therapy (HAART) regimes based on nucleoside reverse
transcriptase inhibitors (NRTIs) have revolutionized the treatment of AIDS in recent years …

▪ Abstract DNA polymerase (pol) γ is the sole DNA polymerase in animal mitochondria.
Biochemical and genetic evidence document a key role for pol γ in mitochondrial DNA …

No therapeutics or vaccines currently exist for human coronaviruses (HCoVs). The Severe
Acute Respiratory Syndrome-associated coronavirus (SARS-CoV) epidemic in 2002–2003 …

Background Nucleoside analogues can induce toxic effects on mitochondria by inhibiting
the human DNA polymerase γ. The toxic effects can range from increased serum lactate …

Nucleoside reverse transcriptase inhibitors (NRTIs) are mainstay therapeutics for HIV that
block retrovirus replication. Alu (an endogenous retroelement that also requires reverse …

To examine the role of the mitochondrial polymerase (Pol γ) in clinically observed toxicity of
nucleoside analogs used to treat AIDS, we examined the kinetics of incorporation catalyzed …

There is emerging evidence that people with successfully treated HIV infection age
prematurely, leading to progressive multi-organ disease, but the reasons for this are not …

DNA polymerases are indispensable for maintaining the integrity of the genome, both
through faithful replication of DNA and by repairing damage to DNA. Among the 16 highly …

How mitochondria process DNA damage and whether a change in the steady-state level of
mitochondrial DNA damage (mtDNA) contributes to mitochondrial dysfunction are questions …

Highly active antiretroviral therapy (HAART) has significantly increased life expectancy of
the human immunodeficiency virus (HIV)-positive population. Nevertheless, the average …