Control over the Na, K-ATPase function plays a central role in adaptation of the organisms to
hypoxic and anoxic conditions. As the enzyme itself does not possess O2 binding sites its …

Cardiometabolic diseases (CMD) are a direct consequence of modern living and contribute
to the development of multisystem diseases such as cardiovascular diseases and diabetes …

In 1972 Neal Bricker presented the “trade-off” hypothesis in which he detailed the role of
physiological adaptation processes in mediating some of the pathophysiology associated …

By maintaining the Na+ and K+ transmembrane gradient mammalian Na, K-ATPase acts as
a key regulator of neuronal electrotonic properties. Na, K-ATPase has an important role in …

Recent studies demonstrated that in addition to Na+, K+-ATPase inhibition cardiotonic
steroids (CTSs) affect diverse intracellular signaling pathways. This study examines the …

During the last two decades numerous research teams demonstrated that skeletal muscles
function as an exercise-dependent endocrine organ secreting dozens of myokines. Variety …

Na+, K+-ATPase is the only known receptor of cardiotonic steroids (CTS) whose interaction
with catalytic α-subunits leads to inhibition of this enzyme. As predicted, CTS affect …

Ouabain is of cardiotonic steroids (CTS) family that is plant-derived compounds and is
known for many years as therapeutic and cytotoxic agents. They are specific inhibitors of Na …

Na+/K+‐ATPase, a transmembrane protein essential for maintaining the electrochemical
gradient across the plasma membrane, acts as a receptor for cardiotonic steroids such as …

With an exception of few reports, the plasma concentration of ouabain and marinobufagenin,
mostly studied cardiotonic steroids (CTS) assessed by immunoassay techniques, is less …