Gastroprotective potential of red onion (Allium cepa L.) peel in ethanol-induced gastric injury in rats: involvement of Nrf2/HO-1 and HMGB-1/NF-κB trajectories

NB Ali, SSA Ibrahim, MA Alsherbiny, E Sheta… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance The utilization of plants with therapeutic properties in
traditional medicine has a longstanding practice. Among them, the well-known Allium cepa …

Exploring the Underlying Mechanisms of Preventive Treatment Related to Dietary Factors for Gastric Diseases

K Qiao, Z Song, L Liang, X Zhou, X Feng… - Journal of Agricultural …, 2024 - ACS Publications
Gastric diseases have emerged as one of the main chronic diseases in humans, leading to
considerable health, social, and economic burdens. As a result, using food or “food and …

[HTML][HTML] Mongolian medicine formulae Ruda-6 alleviates indomethacin-induced gastric ulcer by regulating gut microbiome and serum metabolomics in rats

L Feng, T Bao, L Bai, X Mu, N Ta, M Bao, Y Li… - Journal of …, 2023 - Elsevier
Abstract Ethnopharmacological relevance Ruda-6 (RD-6), a typical traditional Mongolian
medicine formulae consisting of 6 herbs, has been traditionally used in treating gastric …

Miconazole mitigates acetic acid-induced experimental colitis in rats: insight into inflammation, oxidative stress and Keap1/Nrf-2 signaling crosstalk

IA Alsharif, HM Fayed, RF Abdel-Rahman… - Biology, 2022 - mdpi.com
Simple Summary The protective effect of miconazole, sulfasalazine (as a reference drug)
and their combination on acetic acid (AA)-induced ulcerative colitis (UC) in a rat model was …

D-Carvone Attenuates CCl4-Induced Liver Fibrosis in Rats by Inhibiting Oxidative Stress and TGF-ß 1/SMAD3 Signaling Pathway

HA Ogaly, SAA Aldulmani, FAM Al-Zahrani… - Biology, 2022 - mdpi.com
Simple Summary Liver fibrosis is a challenging global health problem resulting in a
significant morbidity and mortality rates worldwide due to its rapid progression to cirrhosis …

Protective Effect of Beta-Carotene against Myeloperoxidase- Mediated Oxidative Stress and Inflammation in Rat Ischemic Brain Injury

HN Althurwi, RF Abdel-Rahman, GA Soliman… - Antioxidants, 2022 - mdpi.com
Oxidative stress and inflammatory reaction play critical roles in ischemia/reperfusion (I/R)
injury in the brain. β-carotene (βCAR) is a naturally occurring pigment present in fruits and …

The effects of dragon fruit (Hylocereus polyrhizus) extract on indomethacin‐induced stomach ulcer in rats

E Toktay, M Yayla, L Sahin… - Journal of Food …, 2022 - Wiley Online Library
The aim of this study was to investigate the effects of red dragon fruit (Hylocereus polyrhizus)
extract (DFE) on the stomach in ulcer model induced by indomethacin in rats. Effects of DFE …

Wild Vitex agnus-castus L.: Phytochemical Characterization, Acute Toxicity, and Bioactive Properties

MA Boujbiha, H Chahdoura, K Adouni, BEC Ziani… - Molecules, 2023 - mdpi.com
Wild Vitex agnus-castus (VAC) is a Mediterranean plant that is rich in bioactive metabolites.
This study aimed to validate, for the first time, the beneficial use of VAC fruits and fruit …

[HTML][HTML] Samarcandin protects against testicular ischemia/reperfusion injury in rats via activation of Nrf2/HO-1-mediated antioxidant responses

MS Abdel-Kader, RF Abdel-Rahman… - Saudi Pharmaceutical …, 2023 - Elsevier
The purpose of this study was to evaluate the effectiveness of samarcandin (SMR) in
preventing testicular injury caused by ischemia/reperfusion (I/R) in rats. Rats were divided …

Apigenin role against thioacetamide-triggered liver fibrosis: deciphering the PPARγ/TGF-β1/NF-κB and the HIF/FAK/AKT pathways

RF Abdel-Rahman, HM Fayed… - Journal of …, 2023 - herbmedpharmacol.com
Introduction: Liver tissue malfunction is a severe worldwide health concern that arises from
various chronic liver conditions. The goal of this investigation was to look into the antifibrotic …