Histone deacetylases (HDACs) are evolutionary conserved enzymes which operate by
removing acetyl groups from histones and other protein regulatory factors, with functional …

It has recently become apparent that RNA, itself the product of transcription, is a major
regulator of the transcriptional process. In particular, long noncoding RNAs (lncRNAs) …

As the process that silences gene expression ensues during development, the stage is set
for the activity of Polycomb-repressive complex 2 (PRC2) to maintain these repressed gene …

The precise timing of cell cycle gene expression is critical for the control of cell proliferation;
de-regulation of this timing promotes the formation of cancer and leads to defects during …

Histone deacetylases (HDACs) are key epigenetic regulators, and transcriptional complexes
with deacetylase function are among the epigenetic corepressor complexes in the nucleus …

Histones are the main structural proteins of eukaryotic chromatin. Histone acetylation/
deacetylation are the epigenetic mechanisms of the regulation of gene expression and are …

Histone deacetylase (HDAC) inhibitors are proven anticancer therapeutics and have
potential in the treatment of many other diseases including HIV infection, Alzheimer's …

Developmentally regulated accessory subunits dictate PRC2 function. Here, we report the
crystal structures of a 120 kDa heterotetrameric complex consisting of Suz12, Rbbp4, Jarid2 …

Over decades of studies, accumulating evidence has suggested that epigenetic
dysregulation is a hallmark of tumours. Post-translational modifications of histones are …

Developmental silencing of fetal globins serves as both a paradigm of spatiotemporal gene
regulation and an opportunity for therapeutic intervention of β-hemoglobinopathy. The …