Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

Abstract N-methyl-D-aspartate (NMDA) receptors mediate a slow component of excitatory
synaptic transmission, are widely distributed throughout the central nervous system, and …

Glutamate and dopamine systems play distinct roles in terms of neuronal signalling, yet both
have been proposed to contribute significantly to the pathophysiology of schizophrenia. In …

Economics and mental health are intertwined. Apart from the accumulating evidence of the
huge economic impacts of mental ill‐health, and the growing recognition of the effects that …

Systemic administration of the local anaesthetic lidocaine is antinociceptive in both acute
and chronic pain states, especially in acute postoperative and chronic neuropathic pain …

Schizophrenia is a heterogeneous psychiatric disorder that is poorly treated with current
therapies. In this brief review, we provide an update regarding the use of animal models to …

Schizophrenia is a psychiatric disorder characterised by symptoms in three domains:
positive (eg delusions, hallucinations), negative (eg social withdrawal, lack of motivation) …

Summary The glycine transporter 1 (GlyT1) plays a crucial role in the regulation of both
inhibitory and excitatory neurotransmission by removing glycine from the synaptic cleft …

Molecular, genetic and pathological evidence suggests that deficits in GABAergic
parvalbumin-positive interneurons contribute to schizophrenia pathophysiology through …

The introduction of atypical antipsychotics (AAPs) since the discovery of its prototypical drug
clozapine has been a revolutionary pharmacological step for treating psychotic patients as …