Overcoming challenges and dogmas to understand the functions of pseudogenes

SW Cheetham, GJ Faulkner, ME Dinger - Nature Reviews Genetics, 2020 - nature.com
Pseudogenes are defined as regions of the genome that contain defective copies of genes.
They exist across almost all forms of life, and in mammalian genomes are annotated in …

The RNA polymerase III–RIG-I axis in antiviral immunity and inflammation

L Naesens, F Haerynck, MU Gack - Trends in immunology, 2023 - cell.com
Nucleic acid sensors survey subcellular compartments for atypical or mislocalized RNA or
DNA, ultimately triggering innate immune responses. Retinoic acid-inducible gene-I (RIG-I) …

GTF3A mutations predispose to herpes simplex encephalitis by disrupting biogenesis of the host-derived RIG-I ligand RNA5SP141

L Naesens, S Muppala, D Acharya, J Nemegeer… - Science …, 2022 - science.org
Herpes simplex virus 1 (HSV-1) infects several billion people worldwide and can cause life-
threatening herpes simplex encephalitis (HSE) in some patients. Monogenic defects in …

Cytogenetic features of rRNA genes across land plants: analysis of the Plant rDNA database

S Garcia, A Kovařík, AR Leitch, T Garnatje - The Plant Journal, 2017 - Wiley Online Library
The online resource http://www. plantrdnadatabase. com/stores information on the number,
chromosomal locations and structure of the 5S and 18S‐5.8 S‐26S (35S) ribosomal DNA s …

Complete genome assembly provides a high‐quality skeleton for pan‐NLRome construction in melon

C Mo, H Wang, M Wei, Q Zeng, X Zhang, Z Fei… - The Plant …, 2024 - Wiley Online Library
SUMMARY Melon (Cucumis melo L.), being under intensive domestication and selective
breeding, displays an abundant phenotypic diversity. Wild germplasm with tolerance to …

Integrative rDNAomics—importance of the oldest repetitive fraction of the eukaryote genome

R Symonová - Genes, 2019 - mdpi.com
Nuclear ribosomal RNA (rRNA) genes represent the oldest repetitive fraction universal to all
eukaryotic genomes. Their deeply anchored universality and omnipresence during …

[HTML][HTML] Structure and evolution of ribosomal genes of insect chromosomes

VE Gokhman, VG Kuznetsova - Insects, 2024 - mdpi.com
Simple Summary The class Insecta constitutes the largest group of terrestrial animals, with
more than a million described species. As in all other animals, insect genomes contain …

Evolving together: Cassandra retrotransposons gradually mirror promoter mutations of the 5S rRNA genes

S Maiwald, L Mann, S Garcia… - Molecular Biology and …, 2024 - academic.oup.com
The 5S rRNA genes are among the most conserved nucleotide sequences across all
species. Similar to the 5S preservation we observe the occurrence of 5S-related …

Divergent subgenome evolution in the allotetraploid frog Xenopus calcaratus

M Knytl, NR Fornaini, B Bergelová, V Gvoždík… - Gene, 2023 - Elsevier
Allopolyploid genomes are divided into compartments called subgenomes that are derived
from lower ploidy ancestors. In African clawed frogs of the subgenus Xenopus (genus …

Large-scale comparative analysis of cytogenetic markers across Lepidoptera

I Provazníková, M Hejníčková, S Visser, M Dalíková… - Scientific reports, 2021 - nature.com
Fluorescence in situ hybridization (FISH) allows identification of particular chromosomes
and their rearrangements. Using FISH with signal enhancement via antibody amplification …