The coiled-coil domain-containing (CCDC) proteins have been implicated in a variety of
physiological and pathological processes. Their functional roles vary from their interaction …

Spermatogenesis is a complex process regulated by a multitude of genes. The identification
and characterization of male-germ-cell-specific genes is crucial to understanding the …

Sperm motility is crucial for successful fertilization. Highly decorated doublet microtubules
(DMTs) form the sperm tail skeleton, which propels the movement of spermatozoa. Using …

Multiple morphological abnormalities of the flagella (MMAF) is a severe disease of male
infertility, while the pathogenetic mechanisms of MMAF are still incompletely understood …

STUDY QUESTION Can exome sequencing identify new genetic causes of
globozoospermia? SUMMARY ANSWER Exome sequencing in 15 cases of unexplained …

Spermatogenesis is a complex process related to male infertility. Till now, the critical genes
and specific mechanisms have not been elucidated clearly. Our objective was to determine …

Cancer dependency maps, which use CRISPR/Cas9 depletion screens to profile the
landscape of genetic dependencies in hundreds of cancer cell lines, have identified context …

High-throughput transcriptomics and proteomics approaches have recently identified a large
number of germ cell–specific genes with many that remain to be studied through functional …

Orderly and stage‐specifically expressed proteins are essential for spermatogenesis, and
proteases play a key role in protein activation and function. The present study aimed to …

Mammalian spermatozoa are produced in the testis through spermatogenesis and matured
in the epididymis to acquire fertilizing ability. Spermatozoa are ejaculated and migrate from …