Interleukin‐21 in autoimmune and inflammatory skin diseases

A Mesas‐Fernández, E Bodner, FJ Hilke… - European Journal of …, 2023 - Wiley Online Library
Studies on the role of interleukins (ILs) in autoimmune and inflammatory diseases allow for
the better understanding of pathologic mechanisms of disease and resha** of treatment …

Potential role of INTERLEUKIN‐17 in the pathogenesis of oral lichen planus: a systematic review with META‐analysis

H Husein‐ElAhmed, M Steinhoff - Journal of the European …, 2022 - Wiley Online Library
Oral lichen planus (OLP) is a chronic inflammatory mucocutaneous disease of unknown
aetiology, which may evolve into squamous cell carcinoma. Recent advances on OLP …

Lichen planus–a clinical guide

F Solimani, S Forchhammer, A Schloegl… - JDDG: Journal der …, 2021 - Wiley Online Library
Lichen planus (LP) is a chronic lichenoid inflammatory disorder of the skin, mucosa and of
the appendages. LP is classically characterized by the presence of a rich infiltration of …

Therapeutic targeting of Th17/Tc17 cells leads to clinical improvement of lichen planus

F Solimani, R Pollmann, T Schmidt, A Schmidt… - Frontiers in …, 2019 - frontiersin.org
Lichen planus (LP) is a common, chronic relapsing inflammatory disorder of the skin and
mucous membranes which often poses a major therapeutic challenge due to its refractory …

The inflammation in cutaneous lichen planus is dominated by IFN‐ϒ and IL‐21—A basis for therapeutic JAK1 inhibition

K Pietschke, J Holstein, K Meier… - Experimental …, 2021 - Wiley Online Library
Cutaneous lichen planus (CLP) and psoriasis (PSO) are both common chronic inflammatory
skin diseases for which development of new treatments requires the identification of key …

The potential roles of Th17 cells in the pathogenesis of oral lichen planus

S Afzali, E Mohammadisoleimani, Y Mansoori… - Inflammation …, 2023 - Springer
Background Oral lichen planus (OLP) is a T cell-mediated chronic autoimmune disease,
whose pathogenesis and etiology are not entirely understood. OLP is characterized by …

Toll-like receptor 9-positive plasmacytoid dendritic cells promote Th17 immune responses in oral lichen planus stimulated by epithelium-derived cathepsin K

Y Miyahara, H Chen, M Moriyama, K Mochizuki… - Scientific reports, 2023 - nature.com
Oral lichen planus (OLP) is a chronic inflammatory disease associated with T cell infiltration.
The crosstalk between oral epithelium and mucosal T cells was considered to be crucial in …

Analysis of oral lichen planus severity on micro‐RNA linked with malignant transformation risks

A Polizzi, S Santonocito, A Distefano… - Oral …, 2024 - Wiley Online Library
Objective The present study evaluated the oral tissue expression of micro‐RNA (miRNAs)
linked to the potential malignant evolution of oral lichen planus (OLP). Furthermore, the …

Differential genotypes of TNF-α and IL-10 for immunological diagnosis in discoid lupus erythematosus and oral lichen planus: A narrative review

R Wang, X Zhang, S Wang - Frontiers in Immunology, 2022 - frontiersin.org
Discoid lupus erythematosus and oral lichen planus are chronic systemic immune system-
mediated diseases with unclear etiology and pathogenesis. The oral mucosa is the common …

Secukinumab in adult patients with lichen planus: efficacy and safety results from the randomized placebo-controlled proof-of-concept PRELUDE study

T Passeron, M Reinhardt, B Ehst, J Weiss… - British Journal of …, 2024 - academic.oup.com
Background Patients with lichen planus (LP) refractory to available therapies often
experience a high disease burden, representing a population with a clear unmet need for …